Ann Rheum Dis:系统性硬化症使用单克隆抗体阻断CCL24可以改善皮肤和肺纤维化

2019-05-27 xiangting MedSci原创

CCL24在皮肤和肺部的炎症及纤维化病理过程中起重要作用。

这项研究目的是评估CCL24趋化因子在系统性硬化症(SSc)中的表达,并使用体外和体内模型评估CCL24/CCR3轴的可能致病作用。还进一步研究了实验动物模型中抗CCL24单克隆抗体(mAb)CM-101抑制细胞活化以及皮肤和肺部炎症和纤维化的功效。

研究人员使用ELISA和荧光免疫组化法测定SSc患者皮肤活检组织中的CCL24水平和CCL24/CCR3表达。使用CCL24处理的皮肤成纤维细胞和内皮细胞或含/不含CM-101的SSc血清观察细胞活化和分化。使用预防和治疗体内博来霉素(BLM)诱导的模型来评估CM-101mAb处理后的实验性皮肤和肺纤维化进展。

SSc患者的循环CCL24水平显著升高。SSc患者皮肤中的CCc24/CCR3表达显著升高。使用CM-101阻断CCL24明显降低了真皮成纤维细胞的活化及其向SSc血清诱导的肌成纤维细胞的转化。CM-101还能够显著抑制CCL24诱导的内皮细胞活化。在BLM诱导的实验动物模型中,CM-101深度抑制皮肤和肺部纤维化及炎症。

CCL24在皮肤和肺部的炎症及纤维化病理过程中起重要作用。使用CM-101mAb抑制CCL24对SSc患者的治疗有潜在益处。

原始出处:

Adi Mor. Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis. Ann Rheum Dis. May 2019.

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    2019-08-15 charl1234567
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    2019-10-14 aids221
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