Precision Oncol:药食本同源:新研究竟发现某些食物抗癌能力强过药物

2017-06-13 佚名 转化医学网

当你正在吃咖喱或者烤苹果时,你一定想不到你正通过一种最简单而且有效的方法防御甚至攻击着世界上最高发的癌症之一——前列腺癌。近日,美国德克萨斯大学奥斯汀分校的科学家发现,诸如咖喱,苹果,姜黄和红葡萄等食物中存在着可以阻碍前列腺癌生长的关键天然化合物。而前列腺癌正是美国乃至全球最常见的癌症之一。该研究对应文章发表于最新上线的Precision Oncology杂志,名为Combinatorial tr

当你正在吃咖喱或者烤苹果时,你一定想不到你正通过一种最简单而且有效的方法防御甚至攻击着世界上最高发的癌症之一——前列腺癌。

近日,美国德克萨斯大学奥斯汀分校的科学家发现,诸如咖喱,苹果,姜黄和红葡萄等食物中存在着可以阻碍前列腺癌生长的关键天然化合物。而前列腺癌正是美国乃至全球最常见的癌症之一。

该研究对应文章发表于最新上线的Precision Oncology杂志,名为Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism,与以往通过实验验证单一化合物的癌症药效不同,德州大学科学家应用一种新颖的技术对上千种存在于植物中的天然化合物进行了抗癌筛选,进而发现并缩小了对于前列腺癌具有最适预防与抑制能力的化合物具体组合。

文章的主要作者,德州大学营养科学与DELL儿科研究所助理教授Stefano Tiziani说:“完成天然化合物库的筛选之后,我们设计了一种不偏不倚的营养补充组合,而随后的动物实验显示我们设计的新方法对前列腺癌的抑制作用甚至比现有前列腺癌药物都要好。”

“除此之外,这项研究的另一个优点是我们能够以完全无毒的方式抑制小鼠的肿瘤生长。”文章的作者补充道。

在过去十几年中,越来越多的癌症研究在植物中发现了潜在的抗癌化合物。诸如姜黄,苹果皮和绿茶等食品中都被发现了具有抗癌功效的天然化合物。这些化合物最大限度地减少了人体发生炎症的概率,而人体内的炎症也正是癌症发生的风险因素之一。因慢性感染,自身免疫性疾病或肥胖等疾病引起慢性炎症会对人体的正常细胞造成损伤进而使人们面临较高的癌症风险。

为了了解单一化合物和不同化合物组合对于前列腺癌的抑制作用,研究人员首先在小鼠和人类的前列腺癌细胞系上测试了142种天然化合物。接着,研究人员在模式动物上测试了抗癌活性最为明显的几种化合物:乌索酸,苹果皮和迷迭香中发现的蜡质天然化学物质;姜黄中发现的亮黄色植物化合物姜黄素和红葡萄及浆果中发现的天然化合物白藜芦醇。

文章的作者Tiziani教授表示:“这些营养物质具有潜在的抗癌能力并能够被我们所轻易获取。 我们只需要在健康饮食中增加这些化合物的浓度,就能够对前列腺癌起到一定的预防作用。”

同时,这项新的研究还揭示了天然植物化合物之间的协同作用。比如乌索酸与姜黄素或白藜芦醇的结合使用可防止癌细胞吞噬谷氨酰胺等对其生长至关重要的物质。为前列腺癌的预防甚至临床干预提供了一个亲民且可行的有效方法。

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    2023-09-28 侠胆医心 来自上海

    #乌索酸#,苹果皮和#迷迭香##姜黄素##白藜芦醇#,这些成分都可能成为天然的#抗癌#药物,对#前列腺癌#起到一定的预防作用,可防止癌细胞吞噬#谷氨酰胺#等对其生长至关重要的物质。

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Jun 15 22:03:27 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416771, encodeId=d2271416e71dc, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Jun 15 02:02:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210532, encodeId=94d6210532be, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jun 14 07:50:39 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210202, encodeId=ba6221020241, content=呀呀,传播一下,给大家分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Jun 13 12:15:17 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2018-02-26 minlingfeng
  4. 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createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Thu Apr 05 07:02:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864942, encodeId=d24b1864942ae, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Feb 26 08:02:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211244, encodeId=d23321124455, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jun 14 07:50:39 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210202, encodeId=ba6221020241, content=呀呀,传播一下,给大家分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Jun 13 12:15:17 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-15 changjiu

    学习了,谢谢分享

    0

  5. 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createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Thu Apr 05 07:02:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864942, encodeId=d24b1864942ae, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Feb 26 08:02:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211244, encodeId=d23321124455, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jun 14 07:50:39 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210202, encodeId=ba6221020241, content=呀呀,传播一下,给大家分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Jun 13 12:15:17 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-15 yhy100201
  6. 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GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-14 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  7. 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channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Jun 14 07:50:39 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210202, encodeId=ba6221020241, content=呀呀,传播一下,给大家分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Jun 13 12:15:17 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-13 Julie W

    呀呀,传播一下,给大家分享学习

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=210183, encodeId=01a5210183f6, content=可以通过这些食物预防前列腺癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jun 13 11:17:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-13 楠博One

    可以通过这些食物预防前列腺癌

    0

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前列腺癌(Prostate cancer,PCa)是西方国家男性最常见的恶性肿瘤。虽然PCa不是中国男性最普遍的肿瘤,但其发病率和死亡率近年来都快速增长。近日,国际杂志J Pathol在线发表了一遍关于前列腺癌转移机制的研究。

PLoS One:体力活动水平与寿命及前列腺癌和膀胱癌之间关系的探究

最近的荟萃分析表明高体力活动水平对前列腺癌和膀胱癌的发展有适度的保护作用,但这些研究分析中存在显着的异质性。研究者意识到,在中国很少有研究调查体力活动与前列腺癌和膀胱癌之间的关联。鉴于以往研究的不一致性,以及体力活动与前列腺癌和膀胱癌之间的关系研究在中国的稀缺性,体力活动与前列腺癌和膀胱癌之间的联系仍然难以确定。