Gastric Cancer :内脏脂肪组织CT衰减和F-18氟脱氧葡萄糖摄取对预测根治性手术切除后胃癌患者生存的意义

2020-03-16 MedSci原创 MedSci原创

背景及目的:本项研究的目的是探究计算机断层扫描(CT)衰减和内脏脂肪组织(VAT)摄取F-18氟脱氧葡萄糖(FDG)的预后意义,以预测腹膜无复发生存期(RFS)以及RFS和总体晚期胃癌(AGC)患者的

背景及目的:本项研究的目的是探究计算机断层扫描(CT)衰减和内脏脂肪组织(VAT)摄取F-18氟脱氧葡萄糖(FDG)的预后意义,以预测腹膜无复发生存期(RFS)以及RFS和总体晚期胃癌(AGC)患者的生存率(OS)。

方法:研究人员回顾性研究了117例行分期FDG正电子发射断层扫描(PET)/ CT和随后的根治性手术切除的AGC患者。从PET / CT图像中测量了内脏脂肪的CT衰减和FDG摄取(SUV)以及原发肿瘤的最大FDG摄取(SUVmaxT)。评估了内脏脂肪减少和SUV与临床组织病理学因素和生存的关系。

结果:内脏脂肪减少与SUV之间存在显着的正相关(p<0.001,r = 0.799)。在相关性分析中,VAT衰减和SUV均与T期,TNM期,肿瘤大小和血小板与淋巴细胞之比呈显着正相关(p<0.05),并且在术后头3年复发的患者与没有复发的患者相比,VAT衰减和SUV显着更高(p<0.05)。高内脏脂肪衰减和SUV的患者显示RFS,腹膜RFS和OS较低值患者明显差(p<0.05)。在多因素生存分析中,VAT衰减与腹膜RFS和OS显着相关,VAT SUV与OS显着相关(p <0.05)。

结论:FDG PET / CT的内脏脂肪CT衰减情况和FDG对VAT的摄取与肿瘤特征相关,并且是AGC患者腹膜RFS和OS的重要预测因素。

原始出处:

Jeong Won Lee. Et al. Significance of CT attenuation and F-18 fluorodeoxyglucose uptake of visceral adipose tissue for predicting survival in gastric cancer patients after curative surgical resection. Gastric Cancer .2020.

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    2020-09-08 skhzy
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createdBy=71f1477, createdName=s_pl2008, createdTime=Wed Apr 22 10:46:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893664, encodeId=87891893664c0, content=<a href='/topic/show?id=4fc4e85161' target=_blank style='color:#2F92EE;'>#gastric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7851, encryptionId=4fc4e85161, topicName=gastric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Tue Sep 08 23:46:33 CST 2020, time=2020-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072927, encodeId=5dea20e29274b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, 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18 02:46:33 CST 2020, time=2020-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586172, encodeId=088315861e260, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Wed Mar 18 02:46:33 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-07-30 许安
  5. 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  6. 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  7. 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    2020-03-18 jeanqiuqiu

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