JCEM:血清甲状旁腺激素可预测冠状动脉造影的2型糖尿病患者死亡率

2020-08-13 MedSci原创 MedSci原创

与没有T2DM的患者相比,PTH是T2DM患者全因死亡率更强的预测因子。

血清甲状旁腺激素(PTH)是调节钙稳态和维生素D代谢的主要激素之一,其血清水平升高已被认为是死亡率的预测指标。到目前为止,尚未明确T2DM对PTH与死亡率之间关联的影响。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在探究T2DM对PTH预测死亡风险能力的影响。

研究人员检测了904例连续就诊且接受冠状动脉造影以评估明确或疑似稳定型冠状动脉疾病(CAD)高加索白人患者血清中PTH水平,他们中有235例T2DM患者。在平均6.3年的随访期间,研究人员前瞻性地记录了死亡人数。

T2DM患者和非T2DM患者在基线时的PTH水平没有显著差异(P=0.307)。Cox回归分析显示,血清PTH水平可强烈预测T2DM患者的全因死亡率(HR=2.35[1.37-4.03];P=0.002),而PTH不能预测T2DM患者的全因死亡率(HR=1.04[0.81-1.32];P=0.766)。PTHxT2DM交互作用显著(P=0.006),表明PTH对T2DM患者的死亡风险的影响明显强于没有糖尿病的个体。调整HbA1c、糖尿病持续时间、经典血管危险因素、血清维生素D水平和肾功能后,PTH对T2DM患者死亡风险的影响仍然显著(HR=2.10[1.10-4.10];P=0.030)。

由此可见,与没有T2DM的患者相比,PTH是T2DM患者全因死亡率更强的预测因子。

原始出处:

Eva Maria Brandtner,et al.Serum Parathyroid Hormone Predicts Mortality in Coronary Angiography Patients with Type 2 Diabetes.JCEM.2020.https://doi.org/10.1210/clinem/dgaa512

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  5. 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  6. 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  7. 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  8. 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createdTime=Sat Aug 15 07:11:33 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494154, encodeId=40871494154d2, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Sat Aug 15 07:11:33 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043283, encodeId=2975104328330, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Aug 13 19:11:33 CST 2020, time=2020-08-13, status=1, ipAttribution=)]
    2020-08-15 sodoo
  9. 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    2020-08-13 misszhang

    谢谢MedSci提供最新的资讯

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