Eur Urol:转移肾细胞癌患者的粪便微生物组分析

2020-09-03 AlexYang MedSci原创

预临床模型和早期临床数据表明肠道微生物组与的实体肿瘤的免疫治疗响应之间存在相互作用,其中包括了转移性肾细胞癌(mRCC)。

预临床模型和早期临床数据表明肠道微生物组与的实体肿瘤的免疫治疗响应之间存在相互作用,其中包括了转移性肾细胞癌(mRCC)。

最近,有研究人员分析鉴定了接受检查点抑制剂(CPI)治疗的mRCC患者的粪便微生物组情况,并评估了CPI治疗过程中与治疗相关的微生物组组成变化情况。研究人员在患者接受nivolumab(77%)治疗或nivolumab联用ipilimumab(23%)治疗前,收集了31名患者的粪便,其中58%的患者获得了临床益处。更大的微生物多样性与CPI治疗的临床益处相关(P=0.001),且多种微生物与临床益处或缺乏益处相关。微生物组时间谱表明,从CPI中获得临床益处的患者中Akkermansia muciniphila的相对丰度增加。

所有时间点所有患者样本的Shannon多样性指数(CB:临床益处;NCB:无临床益处)

最后,研究人员指出,他们的研究证实了之前在mRCC中与CPI相关的微生物组研究结果。微生物组组成的时间变化表明,可以通过调节微生物组来获得更好的CPI结果。

原始出处:

Nicholas J Salgia, Paulo G Bergerot, Manuel Caitano Maia et al. Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti-PD-1 Immune Checkpoint Inhibitors. Eur Urol. August 2020

 

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    2020-09-05 Homburg
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    2020-09-04 ANNIETIGER

    学习学习

    0

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    2020-09-03 ms3000000449926787

    学习!

    0

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