JTIM:再生医学在预防食管狭窄内镜后黏膜下剥离术中的应用进展

2022-06-30 “JTIM”公众号 “JTIM”公众号

首都医科大学附属北京友谊医院消化内科,李鹏教授团队在JTIM杂志2022年第一期发表了题目为“Advances in the application of regenerative med

首都医科大学附属北京友谊医院消化内科,李鹏教授团队在JTIM杂志2022年第一期发表了题目为“Advances in the application of regenerative medicine in prevention of post-endoscopic submucosal dissection for esophageal stenosis”的最新研究论文。

内镜后黏膜下剥离术(ESD)是一种治疗浅表性食管癌的方法,具有明显的优势。然而,ESD后的食管狭窄仍然是一个棘手的问题,尤其是在切除大面积食管黏膜后,这限制了ESD的广泛使用,尤其是在环状病变中。在这种情况下,强烈建议对ESD后的食管狭窄进行预防性治疗。然而,传统的预防方法(类固醇、金属和生物可降解支架、球囊扩张、径向切口等)的疗效和安全性并不令人满意,需要开发新的策略。再生医学在包括食道在内的器官重建方面已经显示出巨大的潜力。在本综述中,我们旨在描述再生医学在预防ESD后食管狭窄方面的现状。细胞注射、细胞片移植和细胞外基质植入已被证实有效。然而,仍然存在许多障碍,需要进一步研究。

图示:再生医学在预防食管狭窄内镜后黏膜下剥离术中的应用。

原始出处:

Advances in the application of regenerative medicine in prevention of post-endoscopic submucosal dissection for esophageal stenosis. JTIM, 2022, 10(1): 28–35.

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