Nat Commun:肠道微生物群影响肝癌外周免疫反应

2021-01-08 haibei MedSci原创

来自NAFLD-HCC微生物群的细菌提取物,而不是来自对照组的细菌提取物,会引起T细胞免疫抑制表型,其特征是调节性T细胞的扩张和CD8 + T细胞的衰减。

肝细胞癌(HCC)是全球癌症相关死亡的第四大原因。慢性肝脏炎症和肝硬化是HCC发病的关键,常见的危险因素包括病毒性肝炎、酒精性肝病和非酒精性脂肪肝病(NAFLD)。全球肥胖和II型糖尿病的流行,使非酒精性脂肪肝(NAFLD-irrhosis)引起的肝硬化成为全球最常见的肝脏疾病,NAFLD相关的HCC(NAFLD-HCC)预计将成为HCC的主要原因。

 

 

据报道,肠道微生物群可调节肝细胞癌(HCC)的免疫反应。最近,研究人员在Nature Communications杂志发文,报导其采用元基因组学和代谢组学研究来表征与非酒精性脂肪性肝病(NAFLD)相关的肝硬化患者(无论是否有HCC)的肠道微生物群,并评估其在体外模型中对外周免疫反应的影响。
研究人员发现,NAFLD-肝硬化患者的微生物群存在失调的特征,随着HCC的发展,微生物群的组成和功能发生转变。NAFLD-HCC中微生物群的基因功能支持短链脂肪酸的产生,这一点得到了代谢组学研究的证实。

 

 

体外研究表明,来自NAFLD-HCC微生物群的细菌提取物,而不是来自对照组的细菌提取物,会引起T细胞免疫抑制表型,其特征是调节性T细胞的扩张和CD8 + T细胞的衰减。
因此,该研究表明,NAFLD-HCC中的肠道微生物群具有独特的微生物组/代谢组特征,并能调节外周免疫反应。

 

原始出处:
Jason Behary et al. Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma. Nature Communications 2021.

 

 

 

 

 

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    2021-12-20 liye789132251
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    2021-07-11 124507acm01暂无昵称

    学习了

    0

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    2021-09-26 liuli5079
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    2021-01-18 KID123

    学习了

    0

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    2021-01-09 12346c4dm64暂无昵称

    肠道微生物目前有新的搞头呢

    0

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    2021-01-09 zb1235672

    学习了

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