PLoS One:便秘可能与过敏性鼻炎相关

2020-10-20 AlexYang MedSci原创

过敏性鼻炎(AR)是一种让人感觉到很有负担的呼吸系统疾病,其病因和病理生理学仍有争议,很可能是多方面因素造成的。累积的证据表明,肠道失调能够导致AR。便秘可能导致肠道微生物菌群的改变,而便秘对AR的临

过敏性鼻炎(AR)是一种让人感觉到很有负担的呼吸系统疾病,其病因和病理生理学仍有争议,很可能是多方面因素造成的。累积的证据表明,肠道失调能够导致AR。便秘可能导致肠道微生物菌群的改变,而便秘对AR的临床影响尚未研究。最近,有研究人员评估便秘患者的AR风险情况。

研究包括了57786名便秘患者和57786名匹配对照。研究发现,便秘患者AR的发生率为32.2‰,是非便秘患者的两倍。在调整了患者的年龄、性别、并存症和用药后,便秘患者AR的风险是无便秘患者的2.3倍(aHR:2.30;95%CI,2.23-2.37)。在便秘队列的亚组分析中,20-39岁的患者AR风险高2.24倍(aHR;95% CI,2.12-2.36);年龄<20岁、40-64岁和≥65岁的患者AR的风险分别高2.09、2.05和2.07倍(aHR;95%CI,1.98-2.20、1.94-2.18和1.92-2.23)。另外,无论性别如何,有无并存症,包括高脂血症、高血压、慢性肾病、慢性肝病、糖尿病、慢性阻塞性肺病、类风湿性关节炎消化不良、肠易激综合征和焦虑症,便秘患者发生AR的可能性均更高。

最后,研究人员指出,便秘可能与AR的风险增加有关。因此,医生应该对便秘患者的AR保持较高的怀疑指数。另外,AR患者的肠道通畅性问题也不容忽视。

原始出处:

Meng-Che Wu , Ming-Shiou Jan , Jeng-Yuan Chiou et al. Constipation might be associated with risk of allergic rhinitis: A nationwide population-based cohort study. PLoS One. Oct 2020

 

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    2020-10-21 ms9000002053426765

    那么,调节肠道菌群的药物对过敏性鼻炎有效吗?

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encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-25 ms3000000449926787

    喝酸奶🤔

    0

  5. 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encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-22 ms2000000956980985

    肺与肠相表里

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=893565, encodeId=aa048935650e, content=那么,调节肠道菌群的药物对过敏性鼻炎有效吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a58b5427009, createdName=ms9000002053426765, createdTime=Wed Oct 21 19:39:26 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047319, encodeId=76f2204e319c4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Oct 29 14:03:07 CST 2020, time=2020-10-29, status=1, ipAttribution=), 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encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-21 gaohar17

    学习学习

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=893350, encodeId=70a389335087, content=便秘可引起诸多疾病,尤其是女性,主要预防, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:55:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893314, encodeId=63078933141b, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba55427589, createdName=ms2000000321272857, createdTime=Tue Oct 20 15:41:32 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893305, encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-20 rayms

    便秘可引起诸多疾病,尤其是女性,主要预防

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=893565, encodeId=aa048935650e, content=那么,调节肠道菌群的药物对过敏性鼻炎有效吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a58b5427009, createdName=ms9000002053426765, createdTime=Wed Oct 21 19:39:26 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047319, encodeId=76f2204e319c4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Oct 29 14:03:07 CST 2020, time=2020-10-29, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=893350, encodeId=70a389335087, content=便秘可引起诸多疾病,尤其是女性,主要预防, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:55:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893314, encodeId=63078933141b, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba55427589, createdName=ms2000000321272857, createdTime=Tue Oct 20 15:41:32 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893305, encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-20 ms2000000321272857

    好神奇

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=893565, encodeId=aa048935650e, content=那么,调节肠道菌群的药物对过敏性鼻炎有效吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a58b5427009, createdName=ms9000002053426765, createdTime=Wed Oct 21 19:39:26 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047319, encodeId=76f2204e319c4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Oct 29 14:03:07 CST 2020, time=2020-10-29, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=893350, encodeId=70a389335087, content=便秘可引起诸多疾病,尤其是女性,主要预防, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Tue Oct 20 17:55:07 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893314, encodeId=63078933141b, content=好神奇, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ba55427589, createdName=ms2000000321272857, createdTime=Tue Oct 20 15:41:32 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893305, encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-20 liyu7822

    通窍

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=893565, encodeId=aa048935650e, content=那么,调节肠道菌群的药物对过敏性鼻炎有效吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a58b5427009, createdName=ms9000002053426765, createdTime=Wed Oct 21 19:39:26 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047319, encodeId=76f2204e319c4, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Oct 29 14:03:07 CST 2020, time=2020-10-29, status=1, ipAttribution=), 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encodeId=d00d8933053c, content=通窍, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Tue Oct 20 15:06:09 CST 2020, time=2020-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893285, encodeId=ba6f893285d3, content=<a href='/topic/show?id=13032e051f7' target=_blank style='color:#2F92EE;'>#便秘#</a>可能与<a href='/topic/show?id=715310398195' target=_blank style='color:#2F92EE;'>#过敏性鼻炎AR#</a>的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27051, encryptionId=13032e051f7, topicName=便秘), TopicDto(id=103981, encryptionId=715310398195, topicName=过敏性鼻炎AR)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Oct 20 14:11:42 CST 2020, time=2020-10-20, status=1, ipAttribution=)]
    2020-10-20 Jessica

    #便秘#可能与#过敏性鼻炎AR#的风险增加有关,肠道菌群的重要性又来了。过敏性鼻炎患者的肠道通畅性问题也不容忽视。

    0

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慢性便秘严重影响老年人生活,需反复就医消耗大量费用,而更多的老年人自行滥用各种泻药,导致依赖药物,甚至发生结肠黑变病,可能诱发或加重肛裂、痔疮、反复发生不全肠梗阻、肠穿孔、疝气、结肠癌、阿尔茨海默病、心脑血管疾病,从而造成更加严重后果。 目前老年人慢性便秘已成为一个各国面临的老龄化社会问题,因此建立一个科学、全面、有效的评估体系,就成为我们刻不容缓的亟待解决的临床问题。

2019 MASCC建议:晚期癌症患者便秘的管理

2019年8月,癌症支持疗法多国学会(MASCC)发布了晚期癌症患者便秘的管理建议,专家组共提出15条推荐,内容涉及便秘的评估,治疗和再评估。为晚期癌症便秘的治疗提供指导。

Clin Gastroenterology H:补充膳食纤维并不能改善功能性便秘患者的临床症状

患有功能性消化不良的患者被认为胃肠道敏感度增加,有些患者还同时患有功能性便秘。

AP&T:埃洛比昔巴特在慢性便秘中的作用与粪便脱氧胆酸有关

胆汁酸来源于胆固醇,主要负责脂肪乳化促进小肠中脂质的消化吸收。此外,它们能调节结肠的分泌和运动,从而导致结肠转运改变。