JAMA Pediatr:瑞典400万参与者,40年随访发现,早产儿成年后心衰风险增加

2021-04-19 MedSci原创 MedSci原创

早产儿成年后心衰风险增加,早产儿心衰风险监测可能需要长期随访直至成年后

全球范围内,虽然新生儿早产率接近11%,大多数早产儿可存活至成年。研究发现,早产与心脏代谢紊乱、次循环异常和心脏重塑风险相关,而这些都是心力衰竭(HF)的高风险因素。有研究称,早产儿成年后患高血压、糖尿病、血脂异常、缺血性心脏病(IHD)和睡眠呼吸障碍的风险增加,而上述疾病均是已知的HF危险因素。

近日研究人员就早产儿成年后的心力衰竭风险进行了考察。

本次研究是人群为基础的全国队列研究,在瑞典进行,数据采集时间从1973年到2015年,包含1973年至2014年间瑞典出生的所有独生子女数据,收集参与者出生胎龄以及住院和门诊中心力衰竭确诊数据。研究的主要终点为出生胎龄与心衰风险。

研究收集了4193069名参与者数据,平均年龄22.5岁。在8500万参与者随访年中,4158人(0.1%)确诊患有HF。与足月分娩人群相比(胎龄39-41周),早产人群(胎龄<37周)在1岁以下(校正HR[aHR]=4.49)、1-17岁(aHR]=4.49)和18-43岁(aHR=1.42)期间确诊HF的风险增加。在18-43岁年龄段,按胎龄进一步分层研究后发现,极早产(22-27周)人群的HR风险为4.72、中度早产(28-33周)为1.93、晚期早产(34-36周)为1.24(95%CI:1.00-1.54),早期儿(37-38周)为1.09,相应的每10万人年HF发病分别为31.7、13.8、8.7和7.3例,而足月分娩为6.6例。上述相关性在排除先天性结构性心脏异常患者后仍然存在。

研究认为,早产儿成年后心衰风险增加,早产儿心衰风险监测可能需要长期随访直至成年后

原始出处:

Casey Crump et al. Association of Preterm Birth With Long-term Risk of Heart Failure Into Adulthood. JAMA Pediatr. April 5, 2021.

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    2022-03-31 feather89
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    2021-04-20 wu3170536

    以后宝妈需要注意了 影响孩子未来人生呢

    0

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    2021-04-20 ZJYYY7

    哦哦哦哦哦

    0

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    2021-04-19 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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