Cerebral Cortex:经常摄入咖啡因可能会影响大脑结构

2021-02-17 MedSci原创 MedSci原创

毫无疑问,咖啡已成为人们生活中必不可少的饮品,据了解,2015年美国咖啡消费达到了742亿美元,咖啡在美国的广泛性甚至高于自来水。

毫无疑问,咖啡已成为人们生活中必不可少的饮品,据了解,2015年美国咖啡消费达到了742亿美元,咖啡在美国的广泛性甚至高于自来水。

咖啡因是一种黄嘌呤生物碱化合物,有特别强烈的苦味。它的化学结构与腺苷相似,于是在体内与腺苷竞争结合受体,使机体得到暂时的兴奋。研究证实,咖啡因能激活和兴奋中枢神经系统、心脏、呼吸系统和骨骼肌,可用于制造长效镇痛药物,可以抵抗困倦、伤风感冒、哮喘和水肿。然而,如果在晚上摄入,它会扰乱我们的睡眠。睡眠不足会反过来影响灰质正如以前的研究所表明的那样。那么,经常摄入咖啡因会不会因为睡眠不好而影响大脑结构?

近日,发表在Cerebral Cortex杂志的一项研究显示,摄入咖啡因并不会导致睡眠不好,却导致大脑灰质发生变化。灰质主要由神经细胞的细胞体组成的中枢神经系统部分,而白质主要包括神经通路,即神经细胞长的延伸部分。

在这项研究中,研究人员收纳了20名健康的年轻人,并被要求服用含咖啡因的胶囊,除此之外不摄入任何其他咖啡因。研究人员在每10天对参与者进行脑部扫描检查灰质体积,而且还通过记录脑电活动(EEG)来分析参与者的睡眠质量。

结果显示,无论参与者服用的是咖啡因胶囊还是安慰剂胶囊,他们的睡眠深度并无差异,但大脑灰质有明显的差异。服用安慰剂10天后——咖啡因戒断,脑灰质的体积比服用咖啡因胶囊的同一时间段内的体积要大。这种差异在包括海马在内的右颞叶内侧尤为明显,海马是大脑中对记忆巩固至关重要的区域。

综上,虽然咖啡因似乎减少了灰质的体积,但在仅10天的咖啡戒断后,灰质有明显的再生。因此,该研究结果并不一定意味着咖啡因的摄入对大脑有负面影响,但是每天摄入咖啡因可能会影响认知功能,未来需要更大规模的研究。

原始出处:

Yu-Shiuan Lin et al, Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial, Cerebral Cortex(2021). DOI: 10.1093/cercor/bhab005

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    2021-02-19 wmr116
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    2021-02-18 ms9000000371260763

    浅尝辄止

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1707354, encodeId=af391e07354f9, content=<a href='/topic/show?id=63764499be' target=_blank style='color:#2F92EE;'>#cerebral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4499, encryptionId=63764499be, topicName=cerebral)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a56f31414366, createdName=ms55066533437992, createdTime=Wed Jun 09 15:09:18 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263949, encodeId=33d41263949fd, content=<a href='/topic/show?id=62c239e74f2' target=_blank style='color:#2F92EE;'>#咖啡因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39774, encryptionId=62c239e74f2, topicName=咖啡因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=316c73, createdName=caoliehu, createdTime=Fri Feb 19 14:09:18 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424029, encodeId=94351424029db, content=<a href='/topic/show?id=34db439533f' target=_blank style='color:#2F92EE;'>#大脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43953, encryptionId=34db439533f, topicName=大脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d9a3889985, createdName=shanyongle, createdTime=Fri Feb 19 14:09:18 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556517, encodeId=a71f155651e5c, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Fri Feb 19 14:09:18 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925183, encodeId=23d192518329, content=浅尝辄止, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210218/ded32d1770b441879976c2f05b394d68/3a0a9dde26724a0a9cfa12c58177d7a4.jpg, createdBy=2e935399106, createdName=ms9000000371260763, createdTime=Thu Feb 18 04:05:28 CST 2021, time=2021-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925169, encodeId=bcfb9251690b, content=啊 喜欢还是喝呗, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210213/87aa48edd7514d1ca78ddca575b4dbd6/91949ea872bd4f2c96b7b641d6526f76.jpg, createdBy=dfbd5459733, createdName=长腿企鹅, createdTime=Thu Feb 18 00:14:38 CST 2021, time=2021-02-18, status=1, ipAttribution=)]
    2021-02-18 长腿企鹅

    啊 喜欢还是喝呗

    0

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