JAMA:DHA与母乳喂养新生儿支气管肺发育不良风险

2020-07-15 MedSci原创 MedSci原创

研究认为,在母乳喂养的孕29周前出生的早产儿中,与安慰剂相比,母体补充二十二碳六烯酸不能显著改善新生儿支气管肺发育不良风险

目前关于母体补充二十二碳六烯酸(DHA)对新生儿支气管肺发育不良影响的证据尚不充分,近日研究人员考察了新生儿期母亲补充DHA对29周前出生婴儿支气管肺发育的影响。
 
研究在16个加拿大新生儿重症监护病房进行,孕29周前分娩的哺乳期妇女在分娩后72小时内登记,随机每天提供1.2克DHA或安慰剂胶囊,直至36周,研究的主要结果是36周经后婴儿支气管肺无发育不良的存活率。有22个次要结果,包括死亡率和支气管肺发育不良。
 
375名母亲(81.3%)和523名婴儿(99.1%)完成了试验。总的来说,DHA组268名婴儿中有147名(54.9%)无支气管肺发育不良存活,安慰剂组255名婴儿中有157名(61.6%,绝对差异:-5.0%;相对风险:0.91)。DHA组的死亡率为6.0%,安慰剂组为10.2%(绝对差异:-3.9%;相对风险:0.61)。DHA组41.7%的存活婴儿发生了支气管肺发育不良,安慰剂组为31.4%(绝对差异:11.5%;相对危险:1.36)。在22个预先指定的次要结果中,19个没有显著差异。
 
研究认为,在母乳喂养的孕29周前出生的早产儿中,与安慰剂相比,母体补充二十二碳六烯酸不能显著改善新生儿支气管肺发育不良风险。
 
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createdName=洪小医, createdTime=Thu Jul 16 11:17:21 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802942, encodeId=06eb802942a4, content=DHA促进神经系统发育, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 16 00:57:37 CST 2020, time=2020-07-16, status=1, ipAttribution=)]
    2020-08-15 lovetcm

    #母乳喂养#是重要的,补充DHA的作用,也许对智力可能有益,但是对支气管肺的发育,暂时还没有看到差异

    0

  5. 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createdName=洪小医, createdTime=Thu Jul 16 11:17:21 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802942, encodeId=06eb802942a4, content=DHA促进神经系统发育, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 16 00:57:37 CST 2020, time=2020-07-16, status=1, ipAttribution=)]
    2020-07-17 villahu
  6. 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createdName=洪小医, createdTime=Thu Jul 16 11:17:21 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802942, encodeId=06eb802942a4, content=DHA促进神经系统发育, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Thu Jul 16 00:57:37 CST 2020, time=2020-07-16, status=1, ipAttribution=)]
    2020-07-17 neurowu
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  8. 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  9. 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    2020-07-16 洪小医

    学习

    0

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    2020-07-16 1240394fm61暂无昵称

    DHA促进神经系统发育

    0

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