Eur Heart J:残留胆固醇水平升高会增加外周动脉疾病、心肌梗塞和缺血性卒中风险

2021-10-18 MedSci原创 MedSci原创

在一般人群中,残余胆固醇水平升高与PAD风险增加5倍相关,且高于心肌梗塞和缺血性卒中。

富含甘油三酯的脂蛋白中的胆固醇(也称为残余胆固醇)具有促动脉粥样硬化的潜力,这一点越来越受到认可。残余胆固醇水平升高与心肌梗塞和缺血性卒中的风险增加有关。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在检验一个假设即残余胆固醇水平升高也与外周动脉疾病(PAD)风险增加相关。

研究人员分析了2003-2015年招募的哥本哈根一般人群研究中的106937名受试者。在长达15年的随访中,1586人被诊断为PAD,2570人被诊断为心肌梗塞,2762人被诊断为缺血性卒中。研究人员还研究了1976-1978年招募的哥本哈根城市心脏研究中的13974名受试者。在长达43年的随访中,1033人被诊断为PAD,2236人被诊断为心肌梗塞,1976人被诊断为缺血性卒中。研究人员根据标准脂质分布计算了残余胆固醇,诊断来自丹麦全国健康登记处。

在哥本哈根一般人群研究中,残余胆固醇水平升高与PAD风险较高相关,对于<0.5mmol/L(19mg/dL),≥1.5mmol/L(58mg/dL)的个体多变量调整风险比(HR)高达4.8(95%置信区间为3.1-7.5)。心肌梗死的相应结果为4.2(2.9-6.1),缺血性卒中的相应结果为1.8(1.4-2.5)。在哥本哈根城市心脏研究中,PAD的相应HR为4.9(2.9-8.5),心肌梗死为2.6(1.8-3.8),缺血性卒中为2.1(1.5-3.1)。

由此可见,在一般人群中,残余胆固醇水平升高与PAD风险增加5倍相关,且高于心肌梗塞和缺血性卒中。

原始出处:

Benjamin Nilsson Wadström.et al.Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study.European Heart Journal.2021.https://doi.org/10.1093/eurheartj/ehab705

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    2021-10-20 仁者大医
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    2021-10-20 slcumt
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