BMJ:结核患者家属结核感染风险研究

2019-10-26 MedSci MedSci原创

研究发现,与暴露于药物敏感结核病的接触相比,多药耐药结核病患者的家属结核病感染的风险增加,但结核病疾病的风险并无差异

近日研究人员考察了肺结核患者家庭接触者表型耐药与肺结核感染和疾病风险的关系。

研究在秘鲁利马开展,根据患者的耐药情况,对3339名结核病患者的10160名家属进行分类,其中6189人属于结核分枝杆菌易感株,1659人属于异烟肼或利福平耐药株,1541人属于多药耐药株(异烟肼和利福平耐药)。随访12个月后,考察结核感染(结核菌素皮试阳性)和活动性疾病(痰涂片或胸片阳性诊断)的发生率。

与药物敏感肺结核患者的家庭接触者相比,耐多药肺结核患者家庭接触者在随访结束时的感染风险提高8%,但暴露于耐多药肺结核的家庭接触者与药物敏感肺结核的家庭接触者发生结核病的相对危险性没有差异(校正危险比为1.28)。

研究发现,与暴露于药物敏感结核病的接触相比,多药耐药结核病患者的家属结核病感染的风险增加,但结核病疾病的风险并无差异。

原始出处:


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    2020-05-27 gaoxiaoe
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    2019-10-26 qingfengqishi5

    学习了,学习了

    0

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