Lenzilumab预防COVID-19“细胞因子风暴”:已开展III期临床试验

2020-10-31 Allan MedSci原创

Humanigen是一家临床阶段的生物制药公司,致力于通过lenzilumab预防和治疗称为“细胞因子风暴”的免疫反应过度。

“细胞因子风暴”是一种不适当的免疫反应,因为细胞因子与免疫细胞间的正反馈回路而产生。当免疫系统对抗病原体时,细胞因子会引导免疫细胞前往受感染处。同时,细胞因子也会激活这些免疫细胞,被激活的免疫细胞则会产生更多的细胞因子。

多达89%的COVID-19住院患者有发生“细胞因子风暴”并发症的风险,“细胞因子风暴”是导致COVID-19死亡的主要原因。

Humanigen是一家临床阶段的生物制药公司,致力于通过lenzilumab预防和治疗称为“细胞因子风暴”的免疫反应过度。lenzilumab作为中和抗体能够中和GM-CSF(粒细胞-巨噬细胞集落刺激因子)。

Humanigen今天宣布,首位COVID-19患者已在美国MedStar华盛顿医院中心接受了lenzilumab的治疗。这项III期随机、双盲、多中心、安慰剂对照临床试验的主要目标是确定lenzilumab是否可以帮助住院的COVID-19患者更快地康复。符合条件的患者可以参加该试验,同时还可以接受治疗医师推荐的其他标准疗法。

 

原始出处:

https://www.firstwordpharma.com/node/1769778?tsid=4

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1916359, encodeId=fcab19163599f, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Sun Aug 22 21:24:08 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809634, encodeId=4f751809634b8, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, 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    2021-03-30 snf701207
  6. 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  7. 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新型冠状病毒(SARS-CoV-2)自入侵我国以来,给我国乃至世界各国造成了巨大的经济损失,也严重威胁着世界各国人民的生命安全。之前的推送已经对免疫系统中各个组分在病毒感染中的作用进行了概述,本次我们

Incyte启动JAK抑制剂芦可替尼治疗COVID-19相关细胞因子风暴III期研究

4月17日,Incyte宣布启动一项代号为RUXCOVID的全球性、随机、双盲、安慰剂对照III期临床试验,计划在全球招募约400名患者,为期29天,主要评估Jakafi(芦可替尼)联合标准护理(So

QRB Discovery :MIT开发出新蛋白,或可阻止COVID-19患者出现细胞因子风暴

Covid-19的主要特征之一是在严重情况下可能会发生过度的免疫反应。这种免疫过度反应的爆发,也称为细胞因子风暴,会损害肺部并可能致命。细胞因子风暴始终是冠状病毒及其他严重感染患者疾病进展及死亡的重要

IL-6试验令人失望后,诺华将测试IL-1单抗canakinumab用于抵抗新冠COVID-19的细胞因子风暴

新型冠状病毒COVID-19患者体内的炎症因子IL-1β水平显着升高。

拓展阅读

仅熬夜4天,死亡率达80%!!Cell:清华大学研究团队发现,“睡眠不足免疫崩溃”的新机制,深层原因在这儿....

Cell:睡眠剥夺会增加大脑中前列腺素D2(PGD2)的水平,而穿过血脑屏障的脑源性PGD2外排的增加,会诱发循环中性粒细胞的聚集和细胞因子风暴综合症,给外周免疫系统带去严重的病理后果。

J Ethnopharmacol:麻杏石甘汤治疗铜绿假单胞菌肺炎的药理作用及机制研究

该研究观察麻杏石甘汤(MXSG)对急性铜绿假单胞菌肺炎的治疗作用并探讨其可能的机制。

ICU“风暴”来袭,这类检验为何如此关键?

新冠肺炎疫情的爆发让“细胞因子风暴”进入大众视野。

Lenzilumab治疗COVID-19住院患者,即将开展III期临床

生物制药公司Humanigen近日宣布,已完成Lenzilumab治疗COVID-19住院患者的III期研究入组工作。该公司预计将于2021年3月公布主要临床数据。

IL-6试验令人失望后,诺华将测试IL-1单抗canakinumab用于抵抗新冠COVID-19的细胞因子风暴

新型冠状病毒COVID-19患者体内的炎症因子IL-1β水平显着升高。

QRB Discovery :MIT开发出新蛋白,或可阻止COVID-19患者出现细胞因子风暴

Covid-19的主要特征之一是在严重情况下可能会发生过度的免疫反应。这种免疫过度反应的爆发,也称为细胞因子风暴,会损害肺部并可能致命。细胞因子风暴始终是冠状病毒及其他严重感染患者疾病进展及死亡的重要