JAHA:身体成分与心血管死亡率之间的性别差异

2021-02-25 MedSci原创 MedSci原创

较高的肌肉量与男性和女性较低的CVD和死亡率有关。但是,在女性中,无论肌肉质量高低,高脂肪量似乎都与较低的CVD死亡风险有关。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在明确身体成分的差异是否会导致心血管疾病(CVD)死亡率的性别差异,研究人员调查了健康男性和女性身体成分组成与CVD死亡率之间的关系。

研究人员评估了11463名20岁以上来自1999年至2004年期间国家健康和营养检查调查中通过双能X线吸收法确定的人体成分数据,以及来自1999年至2014年期间国家健康和营养检查调查中CVD死亡率数据。研究人员将受试者分为4个身体成分组(低肌肉/低脂肪质量组-对照组;低肌肉/高脂肪组;高肌肉/低脂肪组和高肌肉/高脂肪组),并针对CVD与非CVD死亡率进行了调整后的竞争风险分析。

在女性中,高肌肉/高脂肪量与调整后的CVD死亡率显著降低有关(风险比[HR]为0.58;95%CI为0.39-0.86;P=0.01),但高肌肉/低脂肪量组却没有。在男性中,高肌肉/高脂肪(HR为0.74;95%CI为0.53-1.04;P=0.08)和高肌肉/低脂肪(HR为0.40;95%CI为0.21-0.77;P=0.01)与较低的CVD死亡率相关。此外,在按性别分层的调整后竞争风险分析中,女性受试者的CVD发生率往往会随着总脂肪增加而显著降低(总脂肪四分位数:HR为0.56;95%CI为0.34-0.94;P<0.03),而在男性中则并不显著。

由此可见,较高的肌肉量与男性和女性较低的CVD和死亡率有关。但是,在女性中,无论肌肉质量高低,高脂肪量似乎都与较低的CVD死亡风险有关。这一发现突出了健康男性和女性的肌肉质量对于预防CVD风险的重要性,同时也表明与脂肪相关的CVD风险具有性别二态性。

原始出处:

Preethi Srikanthan.et al.Sex Differences in the Association of Body Composition and Cardiovascular Mortality.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017511

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    2021-02-28 妙酒

    这岂不是说明女性胖点好吗

    0

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    2021-02-26 zhaohui6731
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    2021-02-25 ms9000002069853906

    非常好

    0

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