Cell Death & Disease:CCL5能够促进前列腺癌干细胞和转移

2020-04-27 AlexYang MedSci原创

前列腺癌干细胞(PCSCs)在前列腺进展和转移中具有重要作用,是前列腺癌治疗的一个障碍。肿瘤相关的巨噬细胞(TAMs)是肿瘤微环境(TME)中最丰富的免疫细胞群。PCSCs与TAMs之间互作和信号网络

前列腺癌干细胞(PCSCs)在前列腺进展和转移中具有重要作用,是前列腺癌治疗的一个障碍。肿瘤相关的巨噬细胞(TAMs)是肿瘤微环境(TME)中最丰富的免疫细胞群。PCSCs与TAMs之间互作和信号网络的系统调查能够帮助寻找能够抑制PCSCs和转移的关键靶标。

最近,有研究人员阐释了TAMs分泌的CCL5能够显著的促进前列腺癌细胞的迁移、浸润和上皮-间质转化(EMT),以及PCSC在体外的自我更新。QPCR筛选验证了STAT3是CCL5处理前列腺癌细胞后响应最显著的基因。RNA测序和机制探索进一步阐释了CCL5能够通过激活β-连环蛋白/STAT3信号促进PCSCs的自我更新和前列腺癌转移。明显的是,在TAMs中CCL5的敲除不仅能够显著的抑制前列腺癌异种种植的生长和骨转移,同时也抑制了体内试验中PCSCs的自我更新和致瘤性。最后,临床调查和和生物信息学分析表明了前列腺癌患者中,CCL5的高表达与高格林森等级、不良预后、转移以及PCSCs活性的增加有关。

最后,研究人员指出,TAMs/CCL5能够通过激活β-连环蛋白/STAT3信号促进PCSCs的自我更新和前列腺癌转移。他们的研究为开发TAMs/CCL5作为PCSCs清除和转移性前列腺癌预防的潜在分子靶标提供了新的理论基础。

原始出处:

Renlun Huang, Shengqi Wang, Neng Wang et al. CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling. Cell Death & Disease. 16 April 2020

 

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    2021-11-12 湘雅科教

    已拜读,受益匪浅。

    0

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    2020-12-29 维他命
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1069560, encodeId=82171069560d0, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Fri Nov 12 10:40:47 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962006, encodeId=ed70196200611, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Dec 29 23:11:20 CST 2020, time=2020-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871712, encodeId=afc218e171273, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Jul 17 10:11:20 CST 2020, time=2020-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013332, encodeId=b3362013332f9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Feb 25 09:11:20 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025439, encodeId=2bf9102543996, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Thu Apr 30 20:11:20 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531608, encodeId=fb9a15316089d, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Wed Apr 29 11:11:20 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544991, encodeId=3653154499160, content=<a href='/topic/show?id=7a0fe1289c2' target=_blank style='color:#2F92EE;'>#癌干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71289, encryptionId=7a0fe1289c2, topicName=癌干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340013676140, createdName=1249898am19暂无昵称, createdTime=Wed Apr 29 11:11:20 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631346, encodeId=a0081631346ba, content=<a href='/topic/show?id=e210421640' target=_blank style='color:#2F92EE;'>#CCL5#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4216, encryptionId=e210421640, topicName=CCL5)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63d621719915, createdName=lingqf, createdTime=Wed Apr 29 11:11:20 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040728, encodeId=efab1040e28c2, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 27 23:11:20 CST 2020, time=2020-04-27, status=1, ipAttribution=)]
    2020-04-30 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2020-04-29 cy0328
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    2020-04-29 lingqf
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    2020-04-27 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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