Oncotarget:PARP1表达和TP53状态是区分胶质母细胞瘤亚型可靠标记物

2017-08-28 Emma MedSci原创

胶质母细胞瘤(GBM)是星形细胞肿瘤中恶性程度最高的胶质瘤。肿瘤位于皮质下,多数生长于幕上大脑半球各处。

胶质母细胞瘤(GBM)是星形细胞肿瘤中恶性程度最高的胶质瘤。肿瘤位于皮质下,多数生长于幕上大脑半球各处。呈浸润性生长,常侵犯几个脑叶,并侵犯深部结构,还可经胼胝体波及对侧大脑半球。发生部位以额叶最多见。 PARP1是核蛋白,通常参与DNA修复和维持基因组稳定性,研究提示 PARP1在多种肿瘤类型(例如乳腺,卵巢,皮肤,结肠直肠,肺和脑)中过表达,上调的PARP1可以增强肿瘤的抗凋亡特性,导致DNA损伤治疗剂的抗性。有研究报道PARP抑制剂(PARPi)使肿瘤细胞对放射治疗和化学治疗剂敏感,因此研究人员推测PARP1抑制对于胶质母细胞瘤是一个很有前途的治疗目标。

为了探究更好的治疗方案,研究人员从Cancer Genome Atlas的最新胶质瘤数据集中收集了基因组和临床资料,并对GBM组织样本进行PARP1,ATRX,IDH1和p53免疫组化及相关分析,结果显示,由于亚型特异性,PARP1表达水平和TP53突变状态是区分Proneural和Classical亚型的可靠标记候选物,它们在GBM中具有预后和治疗意义。

其中,PARP1增加和mRNA表达增加是高级星形细胞瘤的特征,特别是Proneural和Classical GBM亚型。较高的PARP1水平与Classical亚组中的患者存活率呈反相关(p <0.005)。ATRX(p = 0.006)和TP53(p = 0.015)突变与PARP1表达增加相关,PARP1蛋白水平与ATRX损失和p53过表达相关。此外,更高的PARP1表达与野生型TP53共同显示出较短的生存期(p = 0.039)。

原始出处:
Murnyák B, et al. PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma. Oncotarget. 2017 Jul 11;8(28):46348-46362. doi: 10.18632/oncotarget.18013.

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    2018-01-27 仁医06
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createdName=30397604, createdTime=Tue Jul 31 14:12:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772239, encodeId=b16c1e72239d7, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Feb 05 22:12:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904481, encodeId=31681904481a2, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Mon Feb 19 17:12:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674303, encodeId=89ef16e430322, content=<a href='/topic/show?id=466013e58de' target=_blank style='color:#2F92EE;'>#PARP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13758, encryptionId=466013e58de, topicName=PARP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d93c26968892, createdName=bnjfx@135.com, createdTime=Sun Apr 22 04:12:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372381, encodeId=eb6a13e23812f, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458436, encodeId=635214584362b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475844, encodeId=364a14e584495, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621315, encodeId=7c57162131508, content=<a href='/topic/show?id=49b313e56ad' target=_blank style='color:#2F92EE;'>#PARP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13756, encryptionId=49b313e56ad, topicName=PARP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd4d20248280, createdName=lishiwen, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2018-02-19 wjywjy
  5. [GetPortalCommentsPageByObjectIdResponse(id=1795454, encodeId=f8071e9545447, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Jan 27 06:12:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052872, encodeId=efa520528e2a4, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458436, encodeId=635214584362b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475844, encodeId=364a14e584495, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621315, encodeId=7c57162131508, content=<a href='/topic/show?id=49b313e56ad' target=_blank style='color:#2F92EE;'>#PARP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13756, encryptionId=49b313e56ad, topicName=PARP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd4d20248280, createdName=lishiwen, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1795454, encodeId=f8071e9545447, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Jan 27 06:12:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052872, encodeId=efa520528e2a4, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Jul 31 14:12:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772239, encodeId=b16c1e72239d7, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Feb 05 22:12:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904481, encodeId=31681904481a2, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Mon Feb 19 17:12:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674303, encodeId=89ef16e430322, content=<a href='/topic/show?id=466013e58de' target=_blank style='color:#2F92EE;'>#PARP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13758, encryptionId=466013e58de, topicName=PARP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d93c26968892, createdName=bnjfx@135.com, createdTime=Sun Apr 22 04:12:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372381, encodeId=eb6a13e23812f, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458436, encodeId=635214584362b, content=<a href='/topic/show?id=50a81e6869e' target=_blank style='color:#2F92EE;'>#TP53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17686, encryptionId=50a81e6869e, topicName=TP53)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d276073420, createdName=zblhy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475844, encodeId=364a14e584495, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621315, encodeId=7c57162131508, content=<a href='/topic/show?id=49b313e56ad' target=_blank style='color:#2F92EE;'>#PARP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13756, encryptionId=49b313e56ad, topicName=PARP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd4d20248280, createdName=lishiwen, createdTime=Wed Aug 30 02:12:00 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-30 zhishijing
  7. [GetPortalCommentsPageByObjectIdResponse(id=1795454, encodeId=f8071e9545447, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Jan 27 06:12:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052872, encodeId=efa520528e2a4, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-30 zblhy
  8. 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  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-30 lishiwen
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238029, encodeId=6472238029e3, content=raap1表达似乎在很多肿瘤都可以作为标记物., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a3a71988151, createdName=superpw, createdTime=Mon Aug 28 14:36:56 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 superpw

    raap1表达似乎在很多肿瘤都可以作为标记物.

    0

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