2019 ASCO:Nektar Therapeutics公布其IL-2激动剂Bempeg与Nivolumab联用的临床数据

2019-06-02 不详 MedSci原创

Bempegaldesleukin(NKTR-214,bempeg)是一种在研的、CD122优先的IL-2途径激动剂,旨在通过IL-2β-γ受体提供持续的信号传导。PIVOT-02是一项正在进行的2期研究,评估bempeg与nivolumab联合应用于实体瘤中的潜力。

Nektar Therapeutics的PIVOT-02临床数据将在伊利诺斯州芝加哥举行的2019年美国临床肿瘤学会(ASCO)会议上公布。

Bempegaldesleukin(NKTR-214,bempeg)是一种在研的、CD122优先的IL-2途径激动剂,旨在通过IL-2β-γ受体提供持续的信号传导。PIVOT-02是一项正在进行的2期研究,评估bempeg与nivolumab联合应用于实体瘤中的潜力。

Nektar Therapeutics公司首席科学官Jonathan Zalevsky博士说:"对于该队列中38名可评价疗效的患者,在12个月的随访中,具有34%的完全缓解率。42%的患者靶病变减少了100%,相应的淋巴细胞数据也证明了肿瘤免疫双重治疗方案在连续补充和刺激T细胞方面的益处。"

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    2020-04-09 zhouqu_8
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    2020-03-12 tamgche
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04 20:16:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016652, encodeId=147520166529d, content=<a href='/topic/show?id=90e9121e19f' target=_blank style='color:#2F92EE;'>#MPE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12171, encryptionId=90e9121e19f, topicName=MPE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Thu Dec 12 01:16:00 CST 2019, time=2019-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727998, encodeId=1da61e2799852, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, 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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1912143, encodeId=412d191214358, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Apr 09 02:16:00 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974370, encodeId=cfe319e4370f8, content=<a href='/topic/show?id=fdec1e3842b' target=_blank style='color:#2F92EE;'>#Therapeutic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, 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04 20:16:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016652, encodeId=147520166529d, content=<a href='/topic/show?id=90e9121e19f' target=_blank style='color:#2F92EE;'>#MPE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12171, encryptionId=90e9121e19f, topicName=MPE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Thu Dec 12 01:16:00 CST 2019, time=2019-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727998, encodeId=1da61e2799852, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Dec 11 16:16:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938944, encodeId=00861938944a6, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat Jan 04 04:16:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675252, encodeId=a62116e5252ab, content=<a href='/topic/show?id=04a412633ea' target=_blank style='color:#2F92EE;'>#Nektar#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12633, encryptionId=04a412633ea, topicName=Nektar)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0827209070, createdName=雕雕, createdTime=Fri Dec 06 01:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350821, encodeId=121b1350821f0, content=<a href='/topic/show?id=a2fb1e385a1' target=_blank style='color:#2F92EE;'>#therapeutics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17385, encryptionId=a2fb1e385a1, topicName=therapeutics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 04 07:16:00 CST 2019, time=2019-06-04, status=1, ipAttribution=)]
    2019-12-12 soongzhihua
  7. 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topicName=null, topicId=null, topicList=[TopicDto(id=12633, encryptionId=04a412633ea, topicName=Nektar)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0827209070, createdName=雕雕, createdTime=Fri Dec 06 01:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350821, encodeId=121b1350821f0, content=<a href='/topic/show?id=a2fb1e385a1' target=_blank style='color:#2F92EE;'>#therapeutics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17385, encryptionId=a2fb1e385a1, topicName=therapeutics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 04 07:16:00 CST 2019, time=2019-06-04, status=1, ipAttribution=)]
    2019-12-11 feather89
  8. 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topicName=null, topicId=null, topicList=[TopicDto(id=12633, encryptionId=04a412633ea, topicName=Nektar)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd0827209070, createdName=雕雕, createdTime=Fri Dec 06 01:16:00 CST 2019, time=2019-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350821, encodeId=121b1350821f0, content=<a href='/topic/show?id=a2fb1e385a1' target=_blank style='color:#2F92EE;'>#therapeutics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17385, encryptionId=a2fb1e385a1, topicName=therapeutics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Jun 04 07:16:00 CST 2019, time=2019-06-04, status=1, ipAttribution=)]
    2020-01-04 quxin068
  9. 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    2019-12-06 雕雕
  10. 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谈起广东卫生健康事业的发展情况,逻辑清晰,直击要害,是段宇飞留给记者的深刻印象。作为新组建的省卫生健康委主任,今年参会的段宇飞身份有了变化。从省卫生计生委到省卫生健康委,“虽只有一词之差,却是整个工作理念、工作重心的改变”。3月8日,全国人大代表、省卫生健康委主任段宇飞走进南方报业传媒集团两会访谈室,回应广东卫生健康领域的热点话题,并为2019年的广东医疗工作“划重点”。癌症防治成为今年保障民生重

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2019年5月30日下午,第十三届东方心脏病学会议在上海世博中心召开媒体见面会,大会主席、复旦大学附属中山医院葛均波院士,大会执行主席、上海市医学会心血管病分会第十届主任委员方唯一教授,大会秘书长、复旦大学附属中山医院钱菊英和上海交通大学医学院附属瑞金医院陆国平教授共同出席。

HER2指南者说丨张清媛教授:从《2019 CSCO乳腺癌诊疗指南》更新要点看HER2阳性晚期乳腺癌治疗格局的改变

吡咯替尼(艾瑞妮?)是我国首个具有自主知识产权的抗HER2靶向药物,去年吡咯替尼凭借II期临床研究结果获批HER2阳性乳腺癌晚期一线、二线适应症,在上市7个月后便被写入2019中国临床肿瘤学会(CSCO)乳腺癌诊疗指南,以2A级别推荐用于晚期HER2阳性乳腺癌二线的治疗。我们中心也参与了II期和III期临床研究,入组了很多例患者,见证了它的卓越疗效。

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犹记OCC 2018人工智能“小葛与老葛”,让人印象深刻,小葛在肺栓塞诊断方面的表现更令人大开眼界。

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房间隔缺损(ASD)发病率在先心病中占15%~20%,是临床上最为常见的先天性心脏畸形。幼年时,多数患者者除易患感冒等呼吸道感染外可无症状,活动亦不受限制,随着年龄增长,青年时期可有气急、心悸、乏力等。40岁以后症状加重,常出现心房颤动、心房扑动等心律失常和充血性心衰表现。超过50岁的患者则被定义为老年性ASD。阜外医院的徐仲英教授在CIT2019讲解了老年人房间隔缺损的介入治疗应重点注意的问题。