J Med Life:全麻术后恶心呕吐怎么用药?

2021-02-27 MedSci原创 MedSci原创

恶心是指呕吐前的一种心理上的不安和不适感,呕吐是指上消化道内容物因胸腹肌收缩而回流至口腔,术后恶心呕吐的治疗费用高。近日,比较氟哌啶醇、甲氧氯普胺、右美托咪定、生姜对腹腔镜术后恶心呕吐的影响,发现四种

恶心是指呕吐前的一种心理上的不安和不适感,呕吐是指上消化道内容物因胸腹肌收缩而回流至口腔,术后恶心呕吐的治疗费用高。近日,比较氟哌啶醇、甲氧氯普胺、右美托咪定、生姜对腹腔镜术后恶心呕吐的影响,发现四种药物在术后恶心、呕吐方面无明显差异,结果已发表于J Med Life。

研究纳入伊朗Arak的Valiasr医院的88例接受腹腔镜检查的患者,将其随机分为四组(氟哌啶醇、甲氧氯普胺、右美托咪定和生姜),所有患者均采用芬太尼、咪达唑仑、阿曲库铵和丙泊酚进行全身麻醉。在插管、置管固定、血流动力学条件稳定后,患者接受药物。一组患者接受25μg的右美托咪定。普拉西组在手术完成前30分钟给予10mg甲氧氯普胺。此外,对一组患者给予0.5cc的氟哌啶醇(5mg)。从手术开始,每15分钟记录一次心率、血压和血氧饱和度,直到手术结束。此外,在恢复期、术后2小时和4小时记录恶心和呕吐的发生情况。

 

患者中年龄最小的为30岁,最大的为70岁,平均年龄为48.02±9.31岁。此外,四组中女性人数高于男性。右美托咪定组的血压低于其他四组(P<0.05)。心率最低的是氟哌啶醇组,最高的是普利西组(P<0.05)。四组之间呕吐和恶心的发生无显著差异(P <0.05)。

表1.恶心的发生率

综上所述,该研究结果表明,四种药物在术后恶心、呕吐方面无明显差异。由于每种药物所引起的血流动力学变化,最好根据患者的病情来使用这些药物。生姜也是一种副作用较小的中草药,在没有禁忌症的情况下,这种药物可以成为患者不错的选择。

 

原始出处:

 

Amir Reza Naemi, Vahid Kashanitabar, et al., Comparison of the Effects of Haloperidol, Metoclopramide, Dexmedetomidine and Ginger on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy. J Med Life. Apr-Jun 2020;13(2):206-210. doi: 10.25122/jml-2019-0070.

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    2021-05-19 clmlylxy
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    2021-03-06 寻山郎中

    88例还分了四个组的随机对照?

    0

  4. 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    2021-03-01 1def5843m65(暂无匿称)

    联合用药

    0

  5. 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    2021-03-01 科研科研科研

    恶心呕吐怎么办,怎么用药

    0

  6. 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  7. 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  8. 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    2021-03-01 hb2008ye
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    2021-02-27 wxl882001

    了解

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