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J Hepatol：血清HBV-RNA与肝组织病毒复制、肝组织病理学改变的相关性

2017-09-07 MedSci MedSci原创

HBV-RNACHB核苷酸肝组织病毒复制
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接受核苷酸类似物治疗的患者，其血清HBV-RNA水平不仅能够反映肝脏内共价闭合环状DNA（cccDNA）转录活性，而且还与肝脏组织病理学改变有关。

接受核苷酸类似物治疗的患者，在血清HBV-DNA载量受到抑制的情况下，血清HBV-RNA能否反映肝脏内病毒复制活性，这一问题，目前并不清楚。

近日，上海复旦大学华山医院感染科Wang等完成的一项研究表明，接受核苷酸类似物治疗的患者，其血清HBV-RNA水平不仅能够反映肝脏内共价闭合环状DNA（cccDNA）转录活性，而且还与肝脏组织病理学改变有关。

研究者开展了一项横断面研究，从接受恩替卡韦治疗的患者中获得肝组织和血清样本（患者血清HBV-DNA低于检测下限）。分析血清HBV-RNA水平与外周血、肝组织病毒复制的相关性；同时分析与肝组织病理学关系。采用深度测序分析血清HBV-RNA和肝脏内病毒复制准种。利用原位杂交观察HBV-RNA阳性的肝细胞。

研究结果表明，47例患者中，35例患者血清中可检测出HBV-RNA（74.47%， 2.33-4.80 log10 copies/mL）。血清HBV RNA水平不仅与肝组织HBV-RNA水平、HBV-RNA/cccDNA相关；也与肝组织纤维化分期、炎症分级相关。从准种角度分析，与cccDNA池相比，血清HBV-RNA与同期取样的肝内HBV-RNA的基因同质性更强；在连续取样的标本中，HBV-RNA随时间发生动态改变。原位杂交结果表明，HBV-RNA阳性的肝细胞聚集在病灶，零星分布在肝小叶内，与乙型肝炎表面抗原共定位。

原始出处：

Wang J， Yu Y， Li G， et al. Relationship between serum HBV RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients.J Hepatol， 2017 Sep 1. pii： S0168-8278(17)32261-4. doi： 10.1016/j.jhep.2017.08.021.

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    2018-04-01 mjldent

    #组织病理学#

    0

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    2018-02-20 songbq

    #肝组织#

    0

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    2018-05-04 klivis

    #HBV#

    0

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    2017-11-20 shenxlcyp

    #相关性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1928810, encodeId=e48c1928810bc, content=<a href='/topic/show?id=71f1e771115' target=_blank style='color:#2F92EE;'>#组织病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77711, encryptionId=71f1e771115, topicName=组织病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sun Apr 01 10:22:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808367, encodeId=5a07180836e53, content=<a href='/topic/show?id=e2c68135281' target=_blank style='color:#2F92EE;'>#肝组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81352, encryptionId=e2c68135281, topicName=肝组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue Feb 20 09:22:00 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836633, encodeId=a43318366337b, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri May 04 11:22:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837334, encodeId=3054183e33427, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Nov 20 15:22:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426826, encodeId=a0ea14268265e, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473445, encodeId=f63614e344505, content=<a href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512355, encodeId=7f0a151235574, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241991, encodeId=a216241991b8, content=思路看起来简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/8721ec7dbcb5033728265e41bbd44980.jpg, createdBy=491a2054087, createdName=Dr.ADA, createdTime=Sat Sep 09 01:12:15 CST 2017, time=2017-09-09, status=1, ipAttribution=)]
    2017-09-09 一叶知秋

    #EPA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1928810, encodeId=e48c1928810bc, content=<a href='/topic/show?id=71f1e771115' target=_blank style='color:#2F92EE;'>#组织病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77711, encryptionId=71f1e771115, topicName=组织病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sun Apr 01 10:22:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808367, encodeId=5a07180836e53, content=<a href='/topic/show?id=e2c68135281' target=_blank style='color:#2F92EE;'>#肝组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81352, encryptionId=e2c68135281, topicName=肝组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue Feb 20 09:22:00 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836633, encodeId=a43318366337b, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri May 04 11:22:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837334, encodeId=3054183e33427, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Nov 20 15:22:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426826, encodeId=a0ea14268265e, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473445, encodeId=f63614e344505, content=<a href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512355, encodeId=7f0a151235574, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241991, encodeId=a216241991b8, content=思路看起来简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/8721ec7dbcb5033728265e41bbd44980.jpg, createdBy=491a2054087, createdName=Dr.ADA, createdTime=Sat Sep 09 01:12:15 CST 2017, time=2017-09-09, status=1, ipAttribution=)]
    2017-09-09 jktdtl

    #病理学#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1928810, encodeId=e48c1928810bc, content=<a href='/topic/show?id=71f1e771115' target=_blank style='color:#2F92EE;'>#组织病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77711, encryptionId=71f1e771115, topicName=组织病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sun Apr 01 10:22:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808367, encodeId=5a07180836e53, content=<a href='/topic/show?id=e2c68135281' target=_blank style='color:#2F92EE;'>#肝组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81352, encryptionId=e2c68135281, topicName=肝组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue Feb 20 09:22:00 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836633, encodeId=a43318366337b, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri May 04 11:22:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837334, encodeId=3054183e33427, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Nov 20 15:22:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426826, encodeId=a0ea14268265e, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473445, encodeId=f63614e344505, content=<a href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512355, encodeId=7f0a151235574, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241991, encodeId=a216241991b8, content=思路看起来简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/8721ec7dbcb5033728265e41bbd44980.jpg, createdBy=491a2054087, createdName=Dr.ADA, createdTime=Sat Sep 09 01:12:15 CST 2017, time=2017-09-09, status=1, ipAttribution=)]
    2017-09-09 12498623m96暂无昵称

    #病毒复制#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1928810, encodeId=e48c1928810bc, content=<a href='/topic/show?id=71f1e771115' target=_blank style='color:#2F92EE;'>#组织病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77711, encryptionId=71f1e771115, topicName=组织病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sun Apr 01 10:22:00 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808367, encodeId=5a07180836e53, content=<a href='/topic/show?id=e2c68135281' target=_blank style='color:#2F92EE;'>#肝组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81352, encryptionId=e2c68135281, topicName=肝组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue Feb 20 09:22:00 CST 2018, time=2018-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836633, encodeId=a43318366337b, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri May 04 11:22:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837334, encodeId=3054183e33427, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Nov 20 15:22:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426826, encodeId=a0ea14268265e, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473445, encodeId=f63614e344505, content=<a href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512355, encodeId=7f0a151235574, content=<a href='/topic/show?id=6a15e09150c' target=_blank style='color:#2F92EE;'>#病毒复制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70915, encryptionId=6a15e09150c, topicName=病毒复制)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a2310462124, createdName=12498623m96暂无昵称, createdTime=Sat Sep 09 03:22:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241991, encodeId=a216241991b8, content=思路看起来简单, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/27/8721ec7dbcb5033728265e41bbd44980.jpg, createdBy=491a2054087, createdName=Dr.ADA, createdTime=Sat Sep 09 01:12:15 CST 2017, time=2017-09-09, status=1, ipAttribution=)]
    2017-09-09 Dr.ADA

    思路看起来简单

    0