Ann Surg:LRYGB对胃食管功能的长期效果研究

2016-11-01 MedSci MedSci原创

探讨腹腔镜Roux-en-Y胃旁路手术(LRYGB)对胃食管功能的长期效果。LRYGB被认为是胃食管反流病(GERD)肥胖患者的减肥手术选择之一,然而,LRYGB后,没有对GERD进行长期的仪器评估。选择LRYGB的病态肥胖患者纳入前瞻性研究。术前、术后12个月和60个月,我们通过GERD-HRQoL问卷、胃镜、食管测压和24小时阻抗pH(24-hour MII-pH)监测,进行临床评价。从200

探讨腹腔镜Roux-en-Y胃旁路手术(LRYGB)对胃食管功能的长期效果。

LRYGB被认为是胃食管反流病(GERD)肥胖患者的减肥手术选择之一,然而,LRYGB后,没有对GERD进行长期的仪器评估。

选择LRYGB的病态肥胖患者纳入前瞻性研究。术前、术后12个月和60个月,我们通过GERD-HRQoL问卷、胃镜、食管测压和24小时阻抗pH(24-hour MII-pH)监测,进行临床评价。

从2006年5月到2009年5月,纳入86例患者,72 (84%)例完成了5年的研究。术前24-hour MII-pH监测中,54例患者正常(A组),32例患者诊断为GERD(B组,其中23例酸性反流,9例结合反流[酸性+弱酸性的回流(WAR)])。术前患者的年龄、身体质量指数和合并症,两组相似。在术后12个月和60个月,B组患者的问卷评分显着改善。两组均未发生压力变化;24小时MII-pH监测显示酸暴露显著减少,但两组的WAR增加(A组,从0%到52%到74%;B组,从35%到42%到77%)。在长期随访中,A组有14例(30%)、B组有18例(69%)发现食管炎(P < 0.001)。

LRYGB可以让GERD症状获得有效的改善,减少酸暴露。然而,四分之三的患者其远端远端食管暴露于WAR。

原始出处:


Rebecchi F1, Allaix ME, Ugliono E, Giaccone C, Toppino M, Morino M.Increased Esophageal Exposure to Weakly Acidic Reflux 5 Years After Laparoscopic Roux-en-Y Gastric Bypass.Ann Surg. 2016 Nov;264(5):871-877.

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    2017-07-02 zhangpaul93
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    2016-11-03 zhouqu_8
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    2016-11-01 drmike

    这个研究有意思~

    0