Psychological Medicine:精神分裂症诊疗新指标:GM-WM功能同步性

2022-06-22 MedSci原创 MedSci原创

精神分裂症是一种连接障碍综合症,反映在GM和WM功能之间的同步性中断上。本研究观察到的功能同步性改变的具体模式可能有助于精神分裂症的病理生理学,并突显了GM-WM功能相关作为脑功能研究指标的新颖性。

越来越多的证据表明,白质(WM)中的血氧水平依赖性信号(BOLD)反映了WM的功能活动。精神分裂症患者的这种活动是否发生了改变仍不确定,也不确定它是否与灰质(GM)的既定改变或WM束的微结构有关。近期发表在Psychological Medicine的一篇文章分析了大脑WM束BOLD信号的变化,以及它们与GM区BOLD信号的时间同步性,它们与白质纤维束完整性的关系,以及这些影像指标与未经治疗的精神病的当前疾病症状、严重程度和病程之间的关系。

研究人员招募了153例未经抗精神病治疗的精神分裂症患者和153例健康对照者进行静息功能磁共振成像、扩散张量成像和高分辨率T1加权成像。对比分析两组的WM功能活性的差异,并研究了它们与GM功能活性和WM微观结构的关系。研究了WM部分各向异性(FA)与GM-WM功能同步性的关系。然后,分析了功能影像差异参数与年龄、未经治疗的精神病持续时间(DUP)和症状严重程度的相关性。

精神分裂症患者的广泛脑区的低频波动幅度(ALFF)、GM-WM功能同步性和FA降低。尤其是胼胝体膝部,不仅表现出功能活动的同步性减弱,而且ALFF和FA也降低。胼胝体膝部FA与功能同步性也呈正相关关系。未发现这些异常参数与DUP、症状严重程度之间的显著关联。

未经抗精神病治疗的精神分裂症患者与健康对照组灰质-白质功能相关系数的差异。图示为GM-WM功能相关性存在显著的组间差异的GM区和WM区。球形节点表示GM区域,其大小表示与WM区域显著相关的频率。

本研究的发现提供了有关精神分裂症模型的新信息,精神分裂症是一种连接障碍综合症,反映在GM和WM功能之间的同步性中断上。本研究观察到的功能同步性改变的具体模式可能有助于精神分裂症的病理生理学,并突显了GM-WM功能相关作为脑功能研究指标的新颖性。GM和WM功能活动的同步性普遍减弱,为精神分裂症的功能改变提供了新的证据。将WM功能作为脑系统的一个组成部分,研究其变化规律是未来研究的重要方向。

原文出处:

Liu Naici,Lencer Rebekka,Yang Zhipeng et al. Altered functional synchrony between gray and white matter as a novel indicator of brain system dysconnectivity in schizophrenia.[J] .Psychol Med, 2021, undefined: 1-9.

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    2021-08-15 jeanqiuqiu
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    2021-07-07 kalseyzl
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