Circ-Heart Fail:心外膜脂肪组织与心衰患者结局之间的关系

2021-12-26 MedSci原创 MedSci原创

EAT积累与射血分数中等的HF和射血分数正常的HF患者不良预后相关。这一发现支持了EAT在这些HF患者中的重要意义。

心外膜脂肪组织(EAT)积累被认为在射血分数中等范围且正常的心衰(HF)病理生理学中发挥重要作用,但其对患者结局的影响尚未明确。

近日,心血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章,研究人员旨在评估心脏磁共振测量的EAT体积对射血分数中等的HF和射血分数正常的HF患者的预后价值。

研究人员对参加一项前瞻性多中心研究的患者进行了分析,该研究旨在调查植入式环路记录器在射血分数中等的HF和射血分数正常HF中的价值。EAT体积通过心脏磁共振进行量化。该研究的主要结局是全因死亡率和首次HF住院的复合结局。根据EAT每增加1个SD描述了风险比(HR)和95%CI。

研究人员分析了105名患者(平均年龄为72±8岁,50%为女性,左心室射血分数平均为53±8%)。在24(17-25)个月的中位随访期间,31名患者(30%)因HF死亡或住院。在单变量分析中,EAT与更高的复合结局风险显著相关(HR为1.76[95%CI为1.24-2.50],P=0.001),并且在调整年龄、性别和身体后,EAT仍然与结局相关质量指数(HR为1.61[95%CI为1.13-2.31],P=0.009),并在调整纽约心脏功能分级和脑钠肽前体N端后,仍然相关(HR为1.53[95%CI为1.04–2.24],P=0.03)。此外,EAT仅与全因死亡率(HR为2.06[95%CI为1.26-3.37],P=0.004)和仅HF住院(HR为1.54[95%CI为1.04-2.30],P=0.03)相关。

由此可见,EAT积累与射血分数中等的HF和射血分数正常的HF患者不良预后相关。这一发现支持了EAT在这些HF患者中的重要意义。

原始出处:

Gijs van Woerden,et al.Epicardial Adipose Tissue and Outcome in Heart Failure With Mid-Range and Preserved Ejection Fraction.Circulation:heart failure.2021.https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.121.009238

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    2021-12-28 zhaojie88
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    2021-12-28 slcumt

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