Gastric Cancer: 早期和晚期胃癌中印戒细胞腺癌的临床病理学差异

2019-08-04 不详 MedSci原创

印戒细胞癌是胃癌中一种特定的组织学分类。这种特定组织学类型的存在与较差的病理学表现相关。印戒细胞腺癌患者接受治疗性手术后的预后仍有争议。本项研究旨在探究早期和晚期胃癌中印戒细胞腺癌的临床病理学差异。

背景
印戒细胞癌是癌中一种特定的组织学分类。这种特定组织学类型的存在与较差的病理学表现相关。印戒细胞腺癌患者接受治疗性手术后的预后仍有争议。本项研究旨在探究早期和晚期癌中印戒细胞腺癌的临床病理学差异。

方法
研究人员收集了从1988年1月至2012年12月间,共2971名患者,其中包括819名早期胃癌患者和2152名晚期胃癌患者接受了胃癌的根治性切除术。其中,早期胃癌患者中印戒细胞腺癌185例,晚期胃癌患者中有570例。

结果
印戒细胞腺癌的总发生率为25.4%。研究结果显示,早期胃癌患者印戒细胞腺癌和非印戒细胞腺癌的5年总生存率分别为90.7%和83.2%(P= 0.001)。早期胃癌患者印戒细胞腺癌和非印戒细胞腺癌的5年无病生存率分别为87.4%和81.6%(P= 0.003)。晚期胃癌患者印戒细胞腺癌和非印戒细胞腺癌的5年总生存率分别为32.1%和37.9%(P= 0.041)。晚期胃癌患者印戒细胞腺癌和非印戒细胞腺癌的5年无病生存率分别为28.6%和35.2%(P= 0.037)。印戒细胞腺癌是晚期胃癌总体生存的独立预测因子(P= 0.017)。

结论

印戒细胞腺癌的临床特征和预后在早期和晚期胃癌中有所不同。印戒细胞腺癌是治愈性切除后晚期胃癌的不良预后因素。

原始出处:

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    2020-03-07 skhzy
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    2019-08-29 许安
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    2019-08-06 jktdtl

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