Lancet：英国新冠肺炎感染及相关不良预后风险的种族差异研究

2021-05-09 MedSci原创 MedSci原创

在调整了社会人口统计学、临床和家庭特征的差异后，英国大多数少数民族的SARS-CoV-2检测阳性率以及COVID-19相关的不良预后风险也高于白人

来自英国、美国及巴西的统计数据发现，与白人群体相比，其他少数族裔的SARS-CoV-2感染及COVID-19的不良预后风险较高，造成这一因素的原因可能是多方面的，可能包括社会人口统计学、临床医疗公平和家庭经济特征等。近日研究人员就英国第一波和第二波COVID-19疫情期间，新冠肺炎感染及预后的种族差异进行了考察。

研究人员从OpenSafety平台获得2020年2月至8月（第一波疫情期间）以及2020年9月至12月（第二波疫情期间）间成人电子健康记录数据，包括SARS-CoV-2检测和阳性检测结果、COVID-19相关入院、ICU治疗和死亡数据。根据自我报告的种族，将所有人员分为白人、南亚人、黑人、其他族裔、混血和不明6类，又细分为16个子类别。模型根据年龄、性别、临床因素和共病以及家庭规模进行调整，并按地理区域进行分层。

研究包含17288532 名成年居民，其中108779787名（62.9%）为白人，1025319名（5.9%）为南亚人，340912名（2.0%）为黑人，170484名（1.0%）是混血儿，320788 人（1.9%）为其他种族，4553051人（26.3%）种族不明。在第1波疫情期间，以白种人相比，南亚族裔（调整风险比1.08）、黑人族裔（1.08）和混血人群（1.04）进行SARS-CoV-2感染筛查率略微升高，而其他种族组SARS-CoV-2检测率较低（0.77）。南亚族裔（1.99）、黑人族裔（1.69）、混合种族（1.49）和其他种族（1.20）的SARS-CoV-2阳性风险较高。

SARS-CoV-2阳性率的种族差异

与白人相比，其他种族的COVID-19相关住院（南亚、黑人、混血以及其他种族的相对风险分别为1.48、1.78、1.63和1.54），ICU治疗 (分别为2.18、3.12、2.96和3.18)和死亡风险增加(1.26、1.51、1.41和1.22)。在第2波疫情中，南亚族裔与白人相比，COVID-19相关的住院、ICU治疗和死亡的风险增加，但黑人族裔与第1波疫情相比，其各项风险有所降低。若将其结果进一步细化为16个亚族群后，相关结论的异质性更为明显。

COVID-19相关死亡率的种族差异

在调整了社会人口统计学、临床和家庭特征的差异后，英国大多数少数民族的SARS-CoV-2检测阳性率以及COVID-19相关的不良预后风险也高于白人。

原始出处：

Rohini Mathur et al. Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation， intensive care unit admission， and death in 17 million adults in England： an observational cohort study using the OpenSAFELY platform.Lancet. April 30， 2021.

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#插入话题

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2021-07-18 zhwj

#肺炎感染#

42 0
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2021-08-10 howi

#Lancet#

31 0
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2021-08-21 ms2658711348342440

好吧想看看原文

58 0
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2021-05-11 thinkibmz_44722594

#不良预后#

41 0
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2021-05-11 zhaojie88

#种族差异#

47 0
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2021-05-09 公卫新人

新冠肺炎，疫情何时才能消失

41 0
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2021-05-09 goodbing

顶刊就是不一样，质量很高，内容精彩！学到很多

46 0
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2021-05-09 146f77a4m34暂无昵称

学习

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