BMJ:糖尿病孕妇增加后代早发性心血管疾病风险

2019-12-06 MedSci MedSci原创

糖尿病母亲后代的早发性心血管疾病风险增加

近日研究人员评估了母亲在怀孕前或怀孕期间的糖尿病诊断与后代40岁之前早发性心血管疾病(CVD)之间的关系。

研究在丹麦开展,1977-2016年间,2432000名无先天性心脏病的活产儿童参与。随访从出生开始,一直持续到首次诊断为心血管疾病、死亡,母亲糖尿病,包括I型糖尿病(n=22555)、II型糖尿病(n=6537)以及妊娠糖尿病(n=26272)。研究的主要终点是由医院诊断确定的早发性CVD(不包括先天性心脏病)。

在长达40年的随访中,1153名糖尿病母亲的后代和91 311名非糖尿病母亲的后代被诊断患有心血管疾病。患有糖尿病母亲后代的早发性心血管疾病的总发生率增加了29% (HR:1.29)。40岁时,非糖尿病母亲后代的累积发病率为13.07%,糖尿病与非糖尿病后代的累积发病率差异为4.72%。妊娠前糖尿病(1.34)和妊娠期糖尿病(1.19)均与子代CVD发生率增高有关。研究人员还观察到特异性早发心血管疾病的发病率增加,特别是心力衰竭(1.45)、高血压病(1.78)、深静脉血栓形成(1.82)和肺栓塞(1.91)。从儿童期到40岁,不同年龄组的心血管病发病率都有所增加,有糖尿病并发症的母亲的后代(1.60)的发病率增加更为明显。在患有糖尿病和共病CVD的母亲后代中(1.73),CVD的发生较早,与合并症CVD的增加的影响相关。

研究发现,糖尿病母亲后代的早发性心血管疾病风险增加。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1664087, encodeId=8970166408e44, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Sat Feb 01 08:38:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848908, encodeId=8e47184890816, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Mar 29 15:38:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473214, encodeId=89ab14e32141f, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498665, encodeId=dcd91498665b9, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042857, encodeId=8d97104285e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Dec 06 21:38:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1664087, encodeId=8970166408e44, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Sat Feb 01 08:38:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848908, encodeId=8e47184890816, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Mar 29 15:38:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473214, encodeId=89ab14e32141f, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498665, encodeId=dcd91498665b9, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042857, encodeId=8d97104285e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Dec 06 21:38:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2020-03-29 gaoxiaoe
  3. [GetPortalCommentsPageByObjectIdResponse(id=1664087, encodeId=8970166408e44, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Sat Feb 01 08:38:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848908, encodeId=8e47184890816, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Mar 29 15:38:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473214, encodeId=89ab14e32141f, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498665, encodeId=dcd91498665b9, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042857, encodeId=8d97104285e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Dec 06 21:38:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1664087, encodeId=8970166408e44, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Sat Feb 01 08:38:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848908, encodeId=8e47184890816, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Mar 29 15:38:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473214, encodeId=89ab14e32141f, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498665, encodeId=dcd91498665b9, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042857, encodeId=8d97104285e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Dec 06 21:38:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1664087, encodeId=8970166408e44, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Sat Feb 01 08:38:00 CST 2020, time=2020-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848908, encodeId=8e47184890816, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Mar 29 15:38:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473214, encodeId=89ab14e32141f, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498665, encodeId=dcd91498665b9, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 08 09:38:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042857, encodeId=8d97104285e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Dec 06 21:38:00 CST 2019, time=2019-12-06, status=1, ipAttribution=)]
    2019-12-06 misszhang

    谢谢MedSci提供最新的资讯

    0

相关资讯

《2019年欧洲心脏病学会和欧洲糖尿病研究学会糖尿病管理指南》解读

2019年8月31日欧洲心脏病学会(European Society of Cardiology,ESC)及欧洲糖尿病研究学会(European Association for the Study of Diabetes,EASD)等多个学术团体联合颁布了《2019年ESC/EASD糖尿病管理指南》(以下简称《2019年指南》),对2013年在Eur Heart J上发表的《ESC/EASD DM

Eur Heart J:噪声与心血管疾病关联的神经生物学机制

由此可见,该研究的结果表明噪声暴露与MACE通过一种机制有关,其机制始于与压力相关的边缘系统(杏仁体)活动增加,且包括动脉炎症加剧。这种潜在的神经生物学机制将噪声与CVD联系起来,值得在预期人群中进一步评估。

Sci Rep:生男生女大不同,高龄孕妇男性后代心血管疾病风险明显增高!

前段时间,67岁高龄孕妇产子的消息席卷全国。在二胎开放的当今,高龄孕妇(我国将年龄大于35岁的孕妇定义为高龄孕妇)愈发普遍,但其实,35岁以上的高龄产妇妊娠风险值呈明显上升趋势,出现难产、胎儿发育迟缓、先天性畸形儿以及孕产妇、胎儿死亡的几率要远远大于年轻产妇。

JACC:新胆固醇指南助力高危ASCVD患者的强化降脂治疗

2018年美国心脏协会/美国心脏病学学会(AHA/ACC)胆固醇指南推荐针对动脉粥样硬化性心血管疾病(ASCVD)事件风险极高的患者进行强化降脂治疗。近日,JACC发表的一项研究旨在评估有ASCVD病史的成年人中符合/不符合2018年AHA/ACC胆固醇指南中极高风险定义的事件发生率。

AHA2019丨如何运动和饮食,你的心脏会更健康?

糖尿病是心血管疾病的重要危险因素,而心血管疾病则是糖尿病患者的主要死亡原因。2型糖尿病(T2DM)的成年人可出现心脏舒张功能障碍,此为心力衰竭的先兆。减重或运动是否能改善T2DM的亚临床舒张功能障碍尚不清楚。AHA 2019大会上英国莱斯特大学Gaurav S Gulsin报告的一项研究对此进行了探讨。

AHA2019丨ω-3脂肪酸再续“传奇”,降低心血管事件显获益

AHA 2019大会的多项最新研究结果已陆续发布。其中,REDUCE-IT研究显示,在高甘油三酸酯(TGs)和已知心血管疾病或高发病风险以及已接受他汀类药物治疗低密度脂蛋白胆固醇(LDL-C)水平控制相对良好的患者中,使用一种高剂量纯化形式的ω-3脂肪酸(Icosapent Ethyl)可降低TGs,心血管事件和心血管死亡。REDUCE-IT研究的目的是评估在TGs患者中,与安慰剂相比,Icosa