PDGFRα靶向新药avapritinib在中国台湾申请用于治疗晚期胃肠道间质瘤成人患者

2020-03-29 MedSci MedSci原创

已递交TFDA的临床数据显示，avapritinib在PDGFRα外显子18突变（包括D842V突变）的晚期GIST患者中ORR达 84%，且不良反应大多为1级或2级

已递交TFDA的临床数据显示，avapritinib在PDGFRα外显子18突变（包括D842V突变）的晚期GIST患者中ORR达 84%，且不良反应大多为1级或2级
Avapritinib已于2020年1月获美国FDA批准，是目前首个且唯一上市的GIST精准靶向药物，用于治疗PDGFRα外显子18突变的、不可手术切除或转移性GIST患者

3月27日，基石药业宣布公司已向台湾卫生福利部食品药物管理署（TFDA）提交胃肠道间质瘤（GIST）精准靶向药物avapritinib的上市申请，且该药物已于2020年3月9日获TFDA新药优先审查资格认定。该药物将用于治疗携带血小板衍生生长因子受体α（PDGFRα）外显子18突变（包括PDGFRα D842V突变）的、不可手术切除或转移性GIST成人患者。Avapritinib由公司合作伙伴Blueprint Medicines开发，也是基石药业第二款递交上市申请的药物。

基石药业董事长兼首席执行官江宁军博士表示：“一年内，基石药业已先后递交了两个同类首创（first-in-class）精准靶向药物的上市申请，这不仅体现公司对于临床迫切需求的关注和回应，也显示了公司正顺利向商业化转型。GIST是一种罕见的肿瘤，且目前大中华区已获批的疗法针对PDGFRα D842V突变均无疗效。除台湾外，今年上半年我们计划针对同一适应症在中国大陆递交avapritinib的新药上市申请，以满足更多患者之需。”

基石药业首席医学官杨建新博士表示：“Avapritinib是一种强效、高选择性的在研口服KIT和PDGFRα抑制剂。今年1月，FDA已批准其用于治疗携带PDGFR外显子18突变的不可手术切除或转移性GIST成人患者，成为目前首个且唯一在美国上市的GIST精准靶向药物。目前向TFDA递交的临床数据显示，avapritinib在PDGFRα外显子18突变（包括D842V突变）的晚期GIST患者中显示出前所未有的显著抗肿瘤活性，客观缓解率（ORR）达 84%, 且大多数不良反应均为1级或2级，中位缓解持续时间（DOR）尚未达到，61%的患者DOR≥6个月。"

GIST为发生于胃壁或小肠中的肉瘤，高发年龄为50-80岁。大约90％的GIST的发生与KIT或PDGFRα基因的突变导致的细胞生长失调有关。由于GIST对化疗和放疗不敏感，目前晚期GIST的治疗方案主要为依次使用酪氨酸激酶抑制剂（TKIs）。然而，携带PDGFR外显子18 D842V突变的患者对现有大中华区已批准的TKI药物均不敏感，ORR为0%，中位无进展生存期仅3至5个月，总生存期约15个月。除了D842V之外，既往已批准的GIST治疗药物对于其它罕见的PDGFR外显子18突变疗效也并不理想。

基石药业已与BlueprintMedicines达成独家合作和授权，获得了包括avapritinib在内的多款药物在大中华区的独家开发和商业化授权。BlueprintMedicines保留在世界其他地区开发及商业化相关药物的权利。

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2020-07-28 许安

#靶向新药#

43 0
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2021-02-03 ZGMFX24A

#晚期胃肠道间质瘤#

43 0
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2020-07-18 hxzhang

#VAP#

37 0
[GetPortalCommentsPageByObjectIdResponse(id=1932090, encodeId=170e193209066, content=<a href='/topic/show?id=f71299916ac' target=_blank style='color:#2F92EE;'>#靶向新药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99916, encryptionId=f71299916ac, topicName=靶向新药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 28 11:52:02 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945574, encodeId=34b219455e458, content=<a href='/topic/show?id=1729598e95c' target=_blank style='color:#2F92EE;'>#晚期胃肠道间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59879, encryptionId=1729598e95c, topicName=晚期胃肠道间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Wed Feb 03 18:52:02 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943345, encodeId=161c194334534, content=<a href='/topic/show?id=ea82182e611' target=_blank style='color:#2F92EE;'>#VAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18276, encryptionId=ea82182e611, topicName=VAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f9e287, createdName=hxzhang, createdTime=Sat Jul 18 23:52:02 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669176, encodeId=709716691e6fe, content=<a href='/topic/show?id=1c933024b6' target=_blank style='color:#2F92EE;'>#Avapritinib#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3024, encryptionId=1c933024b6, topicName=Avapritinib)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae0426510371, createdName=july_984, createdTime=Thu Apr 30 23:52:02 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978106, encodeId=907219e81060f, content=<a href='/topic/show?id=d13713952c4' target=_blank style='color:#2F92EE;'>#PDGFRα#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13952, encryptionId=d13713952c4, topicName=PDGFRα)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Apr 02 18:52:02 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040181, encodeId=907920401817c, content=<a href='/topic/show?id=f25a2691f9' target=_blank style='color:#2F92EE;'>#APRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2691, encryptionId=f25a2691f9, topicName=APRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 15 02:52:02 CST 2020, time=2020-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346314, encodeId=5eb7134631482, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e03212, createdName=liao1619, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426031, encodeId=14cf14260313a, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534486, encodeId=316915344867e, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=)]
2020-04-30 july_984

#Avapritinib#

39 0
[GetPortalCommentsPageByObjectIdResponse(id=1932090, encodeId=170e193209066, content=<a href='/topic/show?id=f71299916ac' target=_blank style='color:#2F92EE;'>#靶向新药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99916, encryptionId=f71299916ac, topicName=靶向新药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 28 11:52:02 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945574, encodeId=34b219455e458, content=<a href='/topic/show?id=1729598e95c' target=_blank style='color:#2F92EE;'>#晚期胃肠道间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59879, encryptionId=1729598e95c, topicName=晚期胃肠道间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Wed Feb 03 18:52:02 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943345, encodeId=161c194334534, content=<a href='/topic/show?id=ea82182e611' target=_blank style='color:#2F92EE;'>#VAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18276, encryptionId=ea82182e611, topicName=VAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f9e287, createdName=hxzhang, createdTime=Sat Jul 18 23:52:02 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669176, encodeId=709716691e6fe, content=<a href='/topic/show?id=1c933024b6' target=_blank style='color:#2F92EE;'>#Avapritinib#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3024, encryptionId=1c933024b6, topicName=Avapritinib)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae0426510371, createdName=july_984, createdTime=Thu Apr 30 23:52:02 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978106, encodeId=907219e81060f, content=<a href='/topic/show?id=d13713952c4' target=_blank style='color:#2F92EE;'>#PDGFRα#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13952, encryptionId=d13713952c4, topicName=PDGFRα)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Apr 02 18:52:02 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040181, encodeId=907920401817c, content=<a href='/topic/show?id=f25a2691f9' target=_blank style='color:#2F92EE;'>#APRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2691, encryptionId=f25a2691f9, topicName=APRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 15 02:52:02 CST 2020, time=2020-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346314, encodeId=5eb7134631482, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e03212, createdName=liao1619, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426031, encodeId=14cf14260313a, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534486, encodeId=316915344867e, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=)]
2020-04-02 仁者大医

#PDGFRα#

39 0
[GetPortalCommentsPageByObjectIdResponse(id=1932090, encodeId=170e193209066, content=<a href='/topic/show?id=f71299916ac' target=_blank style='color:#2F92EE;'>#靶向新药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99916, encryptionId=f71299916ac, topicName=靶向新药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 28 11:52:02 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945574, encodeId=34b219455e458, content=<a href='/topic/show?id=1729598e95c' target=_blank style='color:#2F92EE;'>#晚期胃肠道间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59879, encryptionId=1729598e95c, topicName=晚期胃肠道间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Wed Feb 03 18:52:02 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943345, encodeId=161c194334534, content=<a href='/topic/show?id=ea82182e611' target=_blank style='color:#2F92EE;'>#VAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18276, encryptionId=ea82182e611, topicName=VAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f9e287, createdName=hxzhang, createdTime=Sat Jul 18 23:52:02 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669176, encodeId=709716691e6fe, content=<a href='/topic/show?id=1c933024b6' target=_blank style='color:#2F92EE;'>#Avapritinib#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3024, encryptionId=1c933024b6, topicName=Avapritinib)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae0426510371, createdName=july_984, createdTime=Thu Apr 30 23:52:02 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978106, encodeId=907219e81060f, content=<a href='/topic/show?id=d13713952c4' target=_blank style='color:#2F92EE;'>#PDGFRα#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13952, encryptionId=d13713952c4, topicName=PDGFRα)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Apr 02 18:52:02 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040181, encodeId=907920401817c, content=<a href='/topic/show?id=f25a2691f9' target=_blank style='color:#2F92EE;'>#APRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2691, encryptionId=f25a2691f9, topicName=APRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 15 02:52:02 CST 2020, time=2020-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346314, encodeId=5eb7134631482, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e03212, createdName=liao1619, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426031, encodeId=14cf14260313a, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534486, encodeId=316915344867e, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=)]
2020-06-15 hbwxf

#APRI#

40 0
[GetPortalCommentsPageByObjectIdResponse(id=1932090, encodeId=170e193209066, content=<a href='/topic/show?id=f71299916ac' target=_blank style='color:#2F92EE;'>#靶向新药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99916, encryptionId=f71299916ac, topicName=靶向新药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Jul 28 11:52:02 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945574, encodeId=34b219455e458, content=<a href='/topic/show?id=1729598e95c' target=_blank style='color:#2F92EE;'>#晚期胃肠道间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59879, encryptionId=1729598e95c, topicName=晚期胃肠道间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Wed Feb 03 18:52:02 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943345, encodeId=161c194334534, content=<a href='/topic/show?id=ea82182e611' target=_blank style='color:#2F92EE;'>#VAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18276, encryptionId=ea82182e611, topicName=VAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f9e287, createdName=hxzhang, createdTime=Sat Jul 18 23:52:02 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669176, encodeId=709716691e6fe, content=<a href='/topic/show?id=1c933024b6' target=_blank style='color:#2F92EE;'>#Avapritinib#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3024, encryptionId=1c933024b6, topicName=Avapritinib)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae0426510371, createdName=july_984, createdTime=Thu Apr 30 23:52:02 CST 2020, time=2020-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978106, encodeId=907219e81060f, content=<a href='/topic/show?id=d13713952c4' target=_blank style='color:#2F92EE;'>#PDGFRα#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13952, encryptionId=d13713952c4, topicName=PDGFRα)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Apr 02 18:52:02 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040181, encodeId=907920401817c, content=<a href='/topic/show?id=f25a2691f9' target=_blank style='color:#2F92EE;'>#APRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2691, encryptionId=f25a2691f9, topicName=APRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon Jun 15 02:52:02 CST 2020, time=2020-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346314, encodeId=5eb7134631482, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e03212, createdName=liao1619, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426031, encodeId=14cf14260313a, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534486, encodeId=316915344867e, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Tue Mar 31 02:52:02 CST 2020, time=2020-03-31, status=1, ipAttribution=)]
2020-03-31 liao1619

#胃肠道#

21 0
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2020-03-31 zhty5338

#间质瘤#

33 0
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2020-03-31 liuyiping

#GFR#

33 0

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PDGFRα靶向新药avapritinib在中国台湾申请用于治疗晚期胃肠道间质瘤成人患者

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