JAHA:房颤患者炎症生物标志物与心衰住院风险

2021-04-10 MedSci原创 MedSci原创

在大型当代房颤患者样本中,炎症生物标志物能够较好地预测心衰住院。

房颤患者因心力衰竭(HF)住院治疗是很常见的。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员假设炎症生物标记物可以识别这种并发症风险增加的房颤患者。

研究人员前瞻性地纳入了房颤患者。从基线时获得受试者血浆样本,并检测高敏C反应蛋白(hs-CRP)和白细胞介素-6水平。研究人员计算了从0到4的炎症评分(第50和第75百分位之间的每个生物标志物得1分,第75百分位以上的每个生物标志物得2分)。生物标志物和炎症评分与心衰住院的个体之间的相关性通过多变量Cox比例风险模型计算。

该研究共有3784名房颤患者(中位年龄为72岁,24%曾患心衰),他们接受了中位4.0年的随访。hs-CRP和白细胞介素-6的中位(四分位数范围)血浆水平分别为1.64 (0.81-3.69)mg/L和3.42 (2.14-5.60)pg/mL。心衰住院的总发生率为3.04/100人/年,炎症分类中从1.34/100人/年增加到7.31/100人/年。经多变量调整后,这两种生物标志物均与心衰住院风险显著相关(hs-CRP对数转换每增加1个标准差,校正后的风险比[HR]为1.22;95%CI为1.11-1.34;白细胞介素‐6对数转换调整后HR为1.48;95%可信区间为1.35-1.62)。炎症评分也得到了类似的结果(最高和最低评分相比,调整后的HR为2.43;95%置信区间为1.80-3.30;P<0.001)。

由此可见,在大型当代房颤患者样本中,炎症生物标志物能够较好地预测心衰住院。

原始出处:

Alexander P. Benz.et al.Biomarkers of Inflammation and Risk of Hospitalization for Heart Failure in Patients With Atrial Fibrillation.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019168

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    2021-05-05 hukaixun
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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Apr 12 13:40:02 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614590, encodeId=74121614590d2, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Mon Apr 12 13:40:02 CST 2021, time=2021-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955965, encodeId=294d95596580, content=受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba1a2295333, createdName=121f5596m18暂无昵称, createdTime=Sun Apr 11 16:42:21 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031370, encodeId=adbc10313e099, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sun Apr 11 01:40:02 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955797, encodeId=8fbe955e97c3, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23505477368, createdName=ms2000002099164425, createdTime=Sat Apr 10 23:50:51 CST 2021, time=2021-04-10, status=1, ipAttribution=)]
    2021-04-12 zhaohui6731
  5. 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  6. 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  7. [GetPortalCommentsPageByObjectIdResponse(id=2055875, encodeId=626d20558e5e6, content=<a href='/topic/show?id=074651931a0' target=_blank style='color:#2F92EE;'>#心衰住院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51931, encryptionId=074651931a0, topicName=心衰住院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Tue Jul 13 10:40:02 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841659, encodeId=1636184165971, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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  8. 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content=受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba1a2295333, createdName=121f5596m18暂无昵称, createdTime=Sun Apr 11 16:42:21 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031370, encodeId=adbc10313e099, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sun Apr 11 01:40:02 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955797, encodeId=8fbe955e97c3, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2021-04-11 121f5596m18暂无昵称

    受用

    0

  9. 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content=受用, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba1a2295333, createdName=121f5596m18暂无昵称, createdTime=Sun Apr 11 16:42:21 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031370, encodeId=adbc10313e099, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sun Apr 11 01:40:02 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955797, encodeId=8fbe955e97c3, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2021-04-11 心介

    房颤,临床上碰到很多哦

    0

  10. 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    2021-04-10 ms2000002099164425

    666

    0

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