Dig Dis & Sci:小肠细菌过度生长与炎症性肠病患者的症状严重程度相关

2018-06-24 MedSci MedSci原创

在炎症性肠病(IBD)中,抑制小肠细菌过度生长(SIBO)的常见机制包括完整的回盲瓣,胃酸分泌,肠道蠕动和完整的免疫系统,因此SIBO发病率在缺少这些机制的CD患者中相对较高。本项研究旨在确定是否通过减少SIBO来减轻IBD临床活动。

背景
炎症性肠病IBD)中,抑制小肠细菌过度生长(SIBO)的常见机制包括完整的回盲瓣,胃酸分泌,肠道蠕动和完整的免疫系统,因此SIBO发病率在缺少这些机制的CD患者中相对较高。本项研究旨在确定是否通过减少SIBO来减轻IBD临床活动。

方法
本项研究回顾性分析了147例炎性肠病患者,所有患者均进行SIBO呼气测试。对SIBO阳性与SIBO阴性患者进行比较,包括部分Mayo评分或Harvey Bradshaw指数(HBI)的变化,对连续变量使用t检验,对分类变量使用Chi-squared或Fisher精确检验。

结果
SIBO阳性并进行治疗的患者占61.9%,SIBO阴性患者占38.1%。在克罗恩病中,SIBO阳性和阴性组的中位HBI分别从5降至3和5至4(p= 0.005)。在溃疡性结肠炎中,部分梅奥评分分别从2下降到1.5和2到1(p= 0.607)。

结论
本研究考察了IBD人群中SIBO检测和治疗的临床效果。在检测和治疗SIBO后,研究人员观察到HBI显着降低,证明了减少SIBO能减轻IBD患者的肠道炎症。

原始出处:

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    2018-06-26 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-06-24 1201e5c5m39暂无昵称

    学习了

    0

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    2018-06-24 大爰

    学习了谢谢分享!!

    0