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综述：GDF-15在心血管疾病中的研究

2011-12-06 MedSci原创 MedSci原创

GDF-15心血管
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徐昕晔, 李子健, 高炜 北京大学第三医院心内科 GDF-15是转化生长因子β超家族的一员，其他名称还包括PTGF-h, PLAB, GDF15, PDF, NAG-1,和 PL74。正常情况下，GDF-15仅在少量组织表达，如胎盘和中枢神经系统；在其他组织如结肠、肾脏和前列腺有少量表达1。但是当肝脏、肾脏、心脏和肺等器官出现损伤时，GDF-15在上述器官的表达就会明显增加。GDF-15参与了

徐昕晔, 李子健, 高炜 北京大学第三医院心内科 GDF-15是转化生长因子β超家族的一员，其他名称还包括PTGF-h, PLAB, GDF15, PDF, NAG-1,和 PL74。正常情况下，GDF-15仅在少量组织表达，如胎盘和中枢神经系统；在其他组织如结肠、肾脏和前列腺有少量表达1。但是当肝脏、肾脏、心脏和肺等器官出现损伤时，GDF-15在上述器官的表达就会明显增加。GDF-15参与了很多恶性疾病的发生，特别是在前列腺和结直肠肿瘤；GDF-15也参与了一些良性疾病的发生。已经发现在无效造血的患者中，GDF-15作为海帕西汀抑制因子高水平表达；在系统性硬化症相关的肺动脉高压患者中也发现GDF-15升高。近年来，越来越多的研究关注在GDF-15与心血管疾病之间的关系，尤其是在GDF-15与心室重构的关系，以及其作为预测预后的生物标志物意义3。 GDF-15基因定位于19p12-13.1，包括2个外显子分别为Exon I 309bp，在其5’端有71bp的非翻译序列；ExonII 647bp，在其3’端有244bp的非翻译序列，以及一段约1800bp的内含子。GDF-15在193-

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  1. [GetPortalCommentsPageByObjectIdResponse(id=896641, encodeId=fce289664149, content=<a href='/topic/show?id=46f3e900ee' target=_blank style='color:#2F92EE;'>#GDF-15#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7900, encryptionId=46f3e900ee, topicName=GDF-15)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Nov 03 16:11:25 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375855, encodeId=86e33e5855fd, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLA741euAiaWx2WzY8ukNqz02fazhknaDBOtE2rfNlmMDoOnOn2Zq44W5kbRpicicicicrBibrbTudQ85tPg/132, createdBy=a71a5179098, createdName=果果5962, createdTime=Tue Nov 26 11:48:27 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497731, encodeId=0e48149e731fa, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Dec 08 14:09:00 CST 2011, time=2011-12-08, status=1, ipAttribution=)]
    2020-11-03 lovetcm

    #GDF-15#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=896641, encodeId=fce289664149, content=<a href='/topic/show?id=46f3e900ee' target=_blank style='color:#2F92EE;'>#GDF-15#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7900, encryptionId=46f3e900ee, topicName=GDF-15)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Nov 03 16:11:25 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375855, encodeId=86e33e5855fd, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLA741euAiaWx2WzY8ukNqz02fazhknaDBOtE2rfNlmMDoOnOn2Zq44W5kbRpicicicicrBibrbTudQ85tPg/132, createdBy=a71a5179098, createdName=果果5962, createdTime=Tue Nov 26 11:48:27 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497731, encodeId=0e48149e731fa, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Dec 08 14:09:00 CST 2011, time=2011-12-08, status=1, ipAttribution=)]
    2019-11-26 果果5962

    学到了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=896641, encodeId=fce289664149, content=<a href='/topic/show?id=46f3e900ee' target=_blank style='color:#2F92EE;'>#GDF-15#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7900, encryptionId=46f3e900ee, topicName=GDF-15)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Nov 03 16:11:25 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375855, encodeId=86e33e5855fd, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLA741euAiaWx2WzY8ukNqz02fazhknaDBOtE2rfNlmMDoOnOn2Zq44W5kbRpicicicicrBibrbTudQ85tPg/132, createdBy=a71a5179098, createdName=果果5962, createdTime=Tue Nov 26 11:48:27 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497731, encodeId=0e48149e731fa, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Dec 08 14:09:00 CST 2011, time=2011-12-08, status=1, ipAttribution=)]
    2011-12-08 andy2090

    #血管疾病#

    0