CELL:CRISPR技术寻找氧稳态相关的线粒体和脂代谢途径

2020-04-08 MedSci原创 MedSci原创

人体细胞能够感知和适应氧水平的变化。从历史上看,这一领域的许多研究都集中在缺氧诱导因子(HIF)信号转导和活性氧物种(ROS)上。

人体细胞能够感知和适应氧水平的变化。从历史上看,这一领域的许多研究都集中在缺氧诱导因子(HIF)信号转导和活性氧物种(ROS)上。

最近,研究人员在21%、5%和1%的氧气下进行全基因组CRISPR生长筛选,系统地鉴定出在高氧(213个基因)或低氧(109个基因)中具有相对适应性缺陷的基因敲除,其中大多数基因与HIF或ROS没有已知的联系。

许多被认为是必不可少的线粒体通路的基因敲除,包括复合体I和Fe-S生物合成中的酶,在低氧条件下生长得相对较好,因此在低氧条件下可以缓冲缺氧。

相反,在某些细胞类型中,脂质生物合成和过氧体基因的敲除只在低氧时才会导致细胞缺陷。

该资源还提及了一些遗传性疾病,其严重程度可能受氧的调节,并将数百个基因与氧的同源性联系起来。

 

原始出处:

Isha H. Jain et al. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell (2020). DOI:https://doi.org/10.1016/j.cell.2020.03.029

 

 

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    2020-04-27 docwu2019
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    2020-07-30 changfy
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    2020-04-10 yuandd
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    2020-04-10 huangdf
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