IBD: 高压氧疗法在各种表型炎症性肠病中的有效性和安全性分析

2021-05-21 MedSci原创 MedSci原创

氧气是组织修复的重要因素,高压氧疗法(HBOT)已显示出治疗炎症性肠病(IBD)的新希望。

      氧气是组织修复的重要因素,高压氧疗法(HBOT)已显示出治疗炎症性肠病(IBD)的新希望,高压氧疗法是指将氧气压力提高至标准海平面压力(2.0–2.5 ATA)的2至3倍后给予患者治疗,高压氧会导致血浆中的氧气张力增加,并促进氧气向组织中的扩散,从而降低缺氧并触发组织修复。本项研究旨在通过系统荟萃分析展示IBD患者接受HBOT治疗的有效性和安全性。

 

      研究人员收集了截止至2020年11月的所有数据库中的关于HBOT治疗IBD患者的研究论文,并使用随机效应模型,针对每种IBD表型的临床结局,计算了具有95%置信区间(Cis)的总预测价值。

 

      最后总共有19项研究总共809例患者符合条件:3项随机对照试验和16项病例系列。接受高压氧治疗后溃疡性结肠炎患者的临床缓解率为87%,(95%CI,10–100),克罗恩病的临床缓解率为88%(95%CI,46–98),存在肛周病变的CD患者的临床缓解率为60%(95%CI,40–76),有坏疽性脓皮病的患者的临床缓解率为92%(95%CI,38–100)。在12项关于安全性的研究中,有15%的患者(n = 30)有轻微不良事件,但是总体较为安全。

图:高压氧治疗各种不同表型的炎症性肠病的效果展示

      本项研究证实高压氧治疗(HBOT)IBD是安全的,并且与多种IBD表型的临床缓解率显着相关。

 

 

原始出处:

Jeffrey McCurdy. Et al. The Effectiveness and Safety of Hyperbaric Oxygen Therapy in Various Phenotypes of Inflammatory Bowel Disease: Systematic Review With Meta-analysis. Inflammatory Bowel Diseases.2021.

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    2021-05-26 ms5000000023660064

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    2021-05-23 bnurmamat
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    2021-05-23 rgjl
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    2021-05-23 tastas
  6. [GetPortalCommentsPageByObjectIdResponse(id=968785, encodeId=87bb968e853b, content=赚点, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Wed May 26 23:46:59 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263657, encodeId=bbd7126365ea8, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Sun May 23 14:29:35 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401594, encodeId=a58414015949a, content=<a href='/topic/show?id=e3681022810d' target=_blank style='color:#2F92EE;'>#高压氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102281, encryptionId=e3681022810d, topicName=高压氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun May 23 14:29:35 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466564, encodeId=372c146656496, content=<a href='/topic/show?id=621d6402097' target=_blank style='color:#2F92EE;'>#氧疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64020, encryptionId=621d6402097, topicName=氧疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8a786841989, createdName=rgjl, createdTime=Sun May 23 14:29:35 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535304, encodeId=8cbb153530461, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sun May 23 14:29:35 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547440, encodeId=732c154e44022, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Sun May 23 14:29:35 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967652, encodeId=c25796e652cc, content= 学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210522/82279f921e8d4335aef5b550da03af17/5a62ba7275f642249ceaa36647800480.jpg, createdBy=164c5073734, createdName=1459b022m46暂无昵称, createdTime=Sat May 22 08:43:52 CST 2021, time=2021-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967633, encodeId=b89a96e6332a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sat May 22 00:36:00 CST 2021, time=2021-05-22, status=1, ipAttribution=)]
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    2021-05-22 1459b022m46暂无昵称

    学习一下

    0

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    2021-05-22 学医无涯

    学习一下

    0

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尽管炎症性肠病(IBD)主要影响患者的肠道,但是作为一种全身性疾病也会影响身体的其他器官,包括静脉血栓栓塞症(VTE),葡萄膜炎和脓皮病坏疽等。

JCC:减肥手术也能增加炎性肠病的发病风险?

我们已知,肥胖和炎性肠病(IBD)的发病率在全球范围内都在逐渐增加,肥胖与IBD的平行上升促进了肥胖相关炎症在IBD发病机制中的作用研究。

JCC:炎症性肠病中的肥胖与早期入院有关!

  在肥胖流行同时,炎症性肠病(IBD)患病率和发病率也呈全球上升趋势。

Dig Dis Sci:粪便钙卫蛋白可以预测炎症性肠病患者的不良妊娠结局

粪钙卫蛋白(FCP)是炎症反应时胃肠道中中性粒细胞和巨噬细胞分泌的蛋白质,它是用于区分肠易激综合征和炎症性肠病(IBD)的最敏感的非侵入性的指标。