JAHA:伴有COVID-19的心血管疾病患者临床特征和预后

2020-08-17 MedSci原创 MedSci原创

伴有COVID-19的CVD患者全因死亡率很高。中性粒细胞/淋巴细胞比值高可能是危重病人的预兆。超重/肥胖合并冠心病、严重缺氧和呼吸衰竭导致乳酸蓄积与患者不良预后相关。

2019冠状病毒病(COVID-19)已发展成为全球性疫情。伴有COVID-19的血管疾病(CVD)患者具有不同的临床特征和预后。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项研究旨在总结归纳伴有COVID‐19的CVD患者的临床特征和实验室指标,尤其是重症患者。

这项研究纳入了244名被诊断出伴有COVID-19和CVD(高血压、冠心病或心力衰竭)的患者。根据中国国家卫生健康委员会的临时指南,将患者分为重症组(n=36)和非重症组(n=208)。研究人员从患者的病历中收集临床、实验室和结局数据,并在两组之间进行比较。

重症组患者的平均体重指数(BMI)显著高于非重症组。重症组患者的中性粒细胞/淋巴细胞比值、C反应蛋白、降钙素和纤维蛋白原以及入院时D-二聚体水平显著增加。伴有COVID-19的CVD患者的全因死亡率为19.26%;病情恶化的患者冠心病和心力衰竭的比例显著高于康复者。较高的BMI、既往冠心病病史、乳酸积累和氧分压降低与死亡有关。

由此可见,伴有COVID-19的CVD患者全因死亡率很高。中性粒细胞/淋巴细胞比值高可能是危重病人的预兆。超重/肥胖合并冠心病、严重缺氧和呼吸衰竭导致乳酸蓄积与患者不良预后相关。

原始出处:

Yudong Peng.et al.Clinical Characteristics and Prognosis of 244 Cardiovascular Patients Suffering from Coronavirus Disease in Wuhan, China.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/abs/10.1161/JAHA.120.016796

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    2020-08-19 ms5000000741733160

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    2020-08-19 zhaohui6731
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    2020-08-17 ms5000001908858550

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