Int J Pediatr Otorhinolaryngol:扁桃体切除术对儿童过敏性疾病的影响

2020-12-31 AlexYang MedSci原创

扁桃体切除术对过敏性气道疾病的影响尚不十分清楚。最近,有研究人员前瞻性地调查了扁桃体切除术对儿童常年过敏性鼻炎(PAR)和支气管哮喘(BA)的影响。

扁桃体切除术对过敏性气道疾病的影响尚不十分清楚。最近,有研究人员前瞻性地调查了扁桃体切除术对儿童常年过敏性鼻炎(PAR)和支气管哮喘(BA)的影响

研究包括了扁桃体切除术组(手术组)和年龄相匹配的非手术组(对照组),并进行了前瞻性随访。另外还进行了免疫学分析。研究发现,体外过敏原刺激后,扁桃体细胞会产生少量过敏原特异性Th2细胞,即使是敏感的受试者。流式细胞仪分析在扁桃体中检测到比外周血中更多的效应调节T细胞(Tregs)。临床上,手术后手术组的PAR和BA症状有所改善,但对照组没有。手术组总IgE明显低于对照组;术后IgE水平略有上升,但仍较低。致敏受试者术后粉尘螨(Der f)特异性IgE水平升高,但非致敏受试者没有升高。

最后,研究人员指出,扁桃体切除术并没有改善过敏的潜在机制,然而感染和上气道阻塞风险的降低可能会改善过敏性气道疾病症状

原始出处:

Urara Funakoshi, Syuji Yonekura, Tomohisa Iinuma et al. The influence of tonsillectomy on allergic diseases in pediatric patients. Int J Pediatr Otorhinolaryngol. 2020

 

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    2021-12-16 zutt
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