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PLoS One：间质性肺炎患者服用他汀可降低死亡率

2015-11-18 徐媛 MedSci原创

间质性肺炎
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本研究旨在评估间质性肺炎患者服用他汀是否能降低患者死亡率。 研究人员对从从1995到2009年间服用他汀药物的间质性肺炎患者和未服用他汀类药物进行1:2配对研究，被诊断为间质性肺炎的患者来自丹麦。 间质性肺病(n = 1786 + 1786)和先天性非纤维化患者(n = 261 + 261)功能随访累积生存率，服用他汀药物的间质性肺炎患者的生存率比非他汀使用组要高（log-rank:P =

本研究旨在评估间质性肺炎患者服用他汀是否能降低患者死亡率。

研究人员对从从1995到2009年间服用他汀药物的间质性肺炎患者和未服用他汀类药物进行1:2配对研究，被诊断为间质性肺炎的患者来自丹麦。

间质性肺病(n = 1786 + 1786)和先天性非纤维化患者(n = 261 + 261)功能随访累积生存率，服用他汀药物的间质性肺炎患者的生存率比非他汀使用组要高（log-rank:P = 7·10-9，P = 0.05)。使用他汀药物的间质性肺病患者平均存活时间为3.3年，未服用他汀药物患者存活时间为2.1年。先天性肺纤维化患者生存时间对比3.4年和2.4年。调整多重变量后，间质性肺病患者他汀使用患者与非他汀使用患者全因死亡风险比为0.73(95%CI0.68-0.79)，先天性肺纤维化患者为0.76(0.62-0.93)。所有敏感性分析结果是可靠的。

研究结果：间质性肺炎患者服用他汀与降低全因死亡率相关。

原始出处

Vedel-Krogh S1, Nielsen SF1, Nordestgaard BG1.Statin Use Is Associated with Reduced Mortality in Patients with Interstitial Lung Disease.PLoS One. 2015 Oct 16;

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    2016-09-05 doctorJiangchao

    继续关注

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    2016-10-09 zjshifan_98647306

    #间质性#

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    2016-01-29 wang_shengli

    受教啦

    0