Radiology:基于CT平扫腹主动脉钙化定量在预测非症状性成人心血管事件要优于Framingham风险评分?!

2018-11-25 shaosai MedSci原创

本研究旨在验证是否基于CT平扫腹主动脉钙化(AAC)定量在预测非症状性成人心血管事件要优于Framingham风险评分(FRS)。

本研究旨在验证是否基于CT平扫腹主动脉钙化(AAC)定量在预测非症状性成人血管事件要优于Framingham风险评分(FRS)。

本研究共纳入了829例非症状性并行腹部CT平扫的患者,对其进行随访平均11.2 年± 2.8评价血管事件。利用半定量软件定量评价基于CT的AAC作为改良Agatston评分。利用Kaplan-Meier曲线和Cox比例危害模型进行事件-心血管事件分析。利用ROC曲线和净重新分类指数变化比较FRS与AAC的预测能力。

结果为,共有156/829例患者在行CT后出现心血管事件(6.7年± 3.5,包括39 [5%]例心肌梗死和79 [10%]例死亡)。在心血管事件组AAC要明显升高(平均AAC, 3478 vs 664; P < .001)。单变量和多变量Cox模型均显示AAC是预测心血管事件的独立指标,独立于FRS(P < .001)。Kaplan-Meier散点图显示AAC要优于FRS。在所有时间点,AAC的曲线下面积(AUC)要明显高于FRS(例如,2年后,AUC of 0.82 vs 0.64; P = .014)。利用200作为最佳截断值,AAC改善了FRS风险分类和经分类指数达到35.4%。

本研究表明,基于CT腹主动脉钙化是预测远期心血管事件的独立指标,其优于Framingham风险评分。该研究表明,腹部CT平扫中腹主动脉钙化具有额外的临床价值。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1643582, encodeId=1cb81643582c4, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 29 19:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951082, encodeId=d9e3195108287, content=<a href='/topic/show?id=d23b85533c8' target=_blank style='color:#2F92EE;'>#腹主动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85533, encryptionId=d23b85533c8, topicName=腹主动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Tue Oct 29 01:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663284, encodeId=1ca91663284d7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Jul 18 04:01:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415419, encodeId=50b91415419f3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519002, encodeId=5cd115190024b, content=<a href='/topic/show?id=44275455fd' target=_blank style='color:#2F92EE;'>#CT平扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5455, encryptionId=44275455fd, topicName=CT平扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb4811230693, createdName=shenxlcyp, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353636, encodeId=d1a2353636ce, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Sun Nov 25 14:59:10 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353626, encodeId=1d0b353626c3, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Nov 25 12:05:41 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353622, encodeId=99043536229e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sun Nov 25 11:34:37 CST 2018, time=2018-11-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1643582, encodeId=1cb81643582c4, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 29 19:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951082, encodeId=d9e3195108287, content=<a href='/topic/show?id=d23b85533c8' target=_blank style='color:#2F92EE;'>#腹主动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85533, encryptionId=d23b85533c8, topicName=腹主动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Tue Oct 29 01:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663284, encodeId=1ca91663284d7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Jul 18 04:01:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415419, encodeId=50b91415419f3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519002, encodeId=5cd115190024b, content=<a href='/topic/show?id=44275455fd' target=_blank style='color:#2F92EE;'>#CT平扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5455, encryptionId=44275455fd, topicName=CT平扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb4811230693, createdName=shenxlcyp, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353636, encodeId=d1a2353636ce, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Sun Nov 25 14:59:10 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353626, encodeId=1d0b353626c3, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Nov 25 12:05:41 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353622, encodeId=99043536229e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sun Nov 25 11:34:37 CST 2018, time=2018-11-25, status=1, ipAttribution=)]
    2018-11-25 lietome15

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1643582, encodeId=1cb81643582c4, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Tue Oct 29 19:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951082, encodeId=d9e3195108287, content=<a href='/topic/show?id=d23b85533c8' target=_blank style='color:#2F92EE;'>#腹主动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85533, encryptionId=d23b85533c8, topicName=腹主动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Tue Oct 29 01:01:00 CST 2019, time=2019-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663284, encodeId=1ca91663284d7, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Thu Jul 18 04:01:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415419, encodeId=50b91415419f3, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519002, encodeId=5cd115190024b, content=<a href='/topic/show?id=44275455fd' target=_blank style='color:#2F92EE;'>#CT平扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5455, encryptionId=44275455fd, topicName=CT平扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb4811230693, createdName=shenxlcyp, createdTime=Tue Nov 27 02:01:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353636, encodeId=d1a2353636ce, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Sun Nov 25 14:59:10 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353626, encodeId=1d0b353626c3, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Nov 25 12:05:41 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353622, encodeId=99043536229e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sun Nov 25 11:34:37 CST 2018, time=2018-11-25, status=1, ipAttribution=)]
    2018-11-25 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-11-25 orangesking

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