Diabetes Care:叶酸、维生素B6和维生素B12的摄入量与糖尿病发病率的关系

2020-08-01 MedSci原创 MedSci原创

年轻时叶酸摄入与中年糖尿病的发病率呈负相关。所观察到的关联可能部分由与高半胱氨酸水平、胰岛素敏感性和全身性炎症有关的机制所解释。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在前瞻性地评估叶酸、维生素B6和维生素B12的摄入量与糖尿病发病率之间的相关性。

1985–1986年,共有4704名18至30岁且未患糖尿病的美国成年人参加了青年冠状动脉风险发展研究(CARDIA),并在2015–2016年期间进行了监测。在基线、1992-1993年和2005-2006年通过有效的饮食历史问卷进行饮食评估。叶酸、维生素B6和维生素B12的累积平均摄入量用于分析。研究人员通过血浆葡萄糖水平、口服葡萄糖耐量试验、血红蛋白A1c浓度和/或降血糖药物确定糖尿病的发病率。

在30年的随访中(平均20.5±8.9),发生了655例糖尿病。调整潜在混杂因素后,摄入叶酸而非维生素B6或维生素B12与糖尿病的发生率呈负相关。与叶酸总摄入量最低的五分位数相比,五分位数处于2-5的多变量调整后风险比(95%CI)分别为0.85(0.67-1.08)、0.78(0.60-1.02)、0.82(0.62-1.09)和0.70 (0.51-0.97;趋势P=0.02)。叶酸摄入量较高还与血浆同型半胱氨酸水平(趋势P<0.01)和胰岛素水平(趋势P<0.01)相关。在补充剂使用者中,叶酸摄入与血清C反应蛋白水平成反比(趋势P<0.01)。

由此可见,年轻时叶酸摄入与中年糖尿病的发病率呈负相关。所观察到的关联可能部分由与高半胱氨酸水平、胰岛素敏感性和全身性炎症有关的机制所解释。

原始出处:

Jie Zhu.et al.Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence Among American Young Adults: A 30-Year Follow-up Study.Diabetes Care.2020.https://care.diabetesjournals.org/content/early/2020/07/30/dc20-0828

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topicList=[TopicDto(id=79063, encryptionId=bce6e90631c, topicName=维生素B6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74fe7959907, createdName=ms1692810954239974, createdTime=Mon Aug 03 03:40:02 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508554, encodeId=9e681508554b4, content=<a href='/topic/show?id=68b0e9055f7' target=_blank style='color:#2F92EE;'>#维生素B#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79055, encryptionId=68b0e9055f7, topicName=维生素B)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=17599981768, createdName=马龙, createdTime=Mon Aug 03 03:40:02 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805739, encodeId=fefb805e39d2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Aug 02 16:05:26 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
    2020-09-28 lmm397
  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Aug 02 16:05:26 CST 2020, time=2020-08-02, status=1, ipAttribution=)]
    2020-08-18 lovetcm

    年轻时#叶酸#摄入与中年#糖尿病#的发病率呈负相关。所观察到的关联可能部分由与#高半胱氨酸水平##胰岛素敏感性#和全身性炎症有关的机制所解释。同时,也表明各类#维生素#也许会有一定的益处

    0

  6. 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    2020-08-03 马龙
  10. 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    2020-08-02 Jessica

    学习了

    0

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