J Hypertens：更佳血压和LDL水平对复发性卒中和认知障碍研究正在开展

以往有很多研究认为降低血压，以及降低LDL-C水平，可能能减少卒中的复发，以及减少认知障碍的发生。对于血压本身还存在争议，是否存在J型曲线一说。然而，血压与LDL-C相互作用，并不清楚。而且，最佳血压水平与LDL-C水平对卒中复发和认知障碍减少是否有更好的作用，这是值得研究的课题。

一项全球多中心，随机对照，3x2析因设计的试验正在开展，试图解决这一难题。这项研究注册：NCT01563731。这项研究入选均为65岁以上老人，主要终点为卒中复发，次要终点为心血管事件，以及认知障碍的发生；计划招募7500名患者，研究预期2018年结束。研究分组包括SBP < 145-135 mmHg作为收缩压达标组，作为对照；以 SBP < 135-125 mmHg作为中等收缩压达标组；以 SBP < 125 mmHg为低收缩压达标组；另外，LDL-C 2.8 - 1.8 mmol/l 作为高LDL-C达标组；以LDL-C < 1.8 mmol/l 作为低LDL-C达标组；

原始出处：
Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M, Silani V, Bilo G, Corrao G, Zambon A, Scotti L, Zhang X, Wang H, Zhang Y, Zhang X, Guan TR, Berge E, Redon J, Narkiewicz K, Dominiczak A, Nilsson P, Viigimaa M, Laurent S, Agabiti-Rosei E, Wu Z, Zhu D, Rodicio JL, Ruilope LM, Martell-Claros N, Pinto F, Schmieder RE, Burnier M, Banach M, Cifkova R, Farsang C, Konradi A, Lazareva I, Sirenko Y, Dorobantu M, Postadzhiyan A, Accetto R, Jelakovic B, Lovic D, Manolis AJ, Stylianou P, Erdine S, Dicker D, Wei G, Xu C, Xie H, Coca A, O'Brien J, Ford G.Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.J Hypertens. 2014 Jun 27.

Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M, Silani V, Bilo G, Corrao G, Zambon A, Scotti L, Zhang X, Wang H, Zhang Y, Zhang X, Guan TR, Berge E, Redon J, Narkiewicz K, Dominiczak A, Nilsson P, Viigimaa M, Laurent S, Agabiti-Rosei E, Wu Z, Zhu D, Rodicio JL, Ruilope LM, Martell-Claros N, Pinto F, Schmieder RE, Burnier M, Banach M, Cifkova R, Farsang C, Konradi A, Lazareva I, Sirenko Y, Dorobantu M, Postadzhiyan A, Accetto R, Jelakovic B, Lovic D, Manolis AJ, Stylianou P, Erdine S, Dicker D, Wei G, Xu C, Xie H, Coca A, O'Brien J, Ford G.Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. J Hypertens. 2014 Jun 27. [Epub ahead of print]