Curr Eye Res:视网膜脱离和增殖性玻璃体视网膜病变中抗视网膜抗体的水平

2018-03-22 cuiguizhong MedSci原创

日本仙台东北大学医学研究院眼科的Ichinohasama R近日在Curr Eye Res发表了一项工作,他们研究了眼内抗视网膜抗体与孔源性视网膜脱离(RRD)和增殖性玻璃体视网膜病变(PVR)患者的临床测量之间的相关性。

日本仙台东北大学医学研究院眼科的Ichinohasama R近日在Curr Eye Res发表了一项工作,他们研究了眼内抗视网膜抗体与孔源性视网膜脱离(RRD)和增殖性玻璃体视网膜病变(PVR)患者的临床测量之间的相关性。

他们从RRD患者、PVR患者和黄斑裂孔对照者中收集房水和玻璃体样本。对总蛋白(TP)、IgG和抗视网膜抗体的水平分别用二辛可宁酸测定法、酶联免疫吸附测定法和斑点印迹测定等方法进行研究。使用Pearson's相关分析对这些测量参数之间的相关性进行评估。方差分析后使用事后检验或Student t检验来比较组间差异。

结果他们发现,抗视网膜抗体和IgG水平相互关联(P <0.010)。 PVR患者的IgG浓度在房水(P <0.001)和玻璃体(P <0.001)中均高于对照组,但在RRD患者中无此现象。相反,来自RRD和PVR患者的两种眼组织样本中的TP水平和抗视网膜抗体水平与对照组之间没有显着差异。在亚组分析中,玻璃体抗视网膜抗体水平与黄斑裂变RRD / PVR手术后重新附着的黄斑中的平均黄斑厚度相关(P = 0.012)。此外,术后囊样黄斑水肿患者的玻璃体抗视网膜抗体水平高于未患者(P = 0.009)。

因此,他们认为,在RRD或PVR手术干预后,眼内黄斑病变的玻璃体内抗视网膜抗体增加。

原文出处:

Ichinohasama, R., et al., Levels of Anti-Retinal Antibodies in Retinal Detachment and Proliferative Vitreoretinopathy. Curr Eye Res, 2018: p. 1-6.

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topicName=玻璃体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Fri Mar 23 15:07:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413935, encodeId=d0bf14139356d, content=<a href='/topic/show?id=27b290e82f4' target=_blank style='color:#2F92EE;'>#视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Fri Mar 23 15:07:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270025, encodeId=fda012e002510, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, 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level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Mar 22 08:23:46 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298561, encodeId=03eb29856132, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Mar 22 08:16:14 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298547, encodeId=b88329854e8b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:51 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298546, encodeId=66a2298546d5, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:44 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298545, encodeId=5b4d29854511, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-23 zutt
  5. 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level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Mar 22 08:23:46 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298561, encodeId=03eb29856132, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Mar 22 08:16:14 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298547, encodeId=b88329854e8b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:51 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298546, encodeId=66a2298546d5, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:44 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298545, encodeId=5b4d29854511, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 飛歌

    学习了很有用

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:51 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298546, encodeId=66a2298546d5, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:44 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298545, encodeId=5b4d29854511, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 明月清辉

    谢谢分享.学习了

    0

  7. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  8. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 Y—xianghai

    学习了新知识

    0

  9. 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level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Mar 22 08:23:46 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298561, encodeId=03eb29856132, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Mar 22 08:16:14 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298547, encodeId=b88329854e8b, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 Y—xianghai

    学习了新知识

    0

  10. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Mar 22 07:14:38 CST 2018, time=2018-03-22, status=1, ipAttribution=)]
    2018-03-22 Y—xianghai

    学习了新知识

    0

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Sci Rep:机器学习技术可以利用超宽域眼底图像诊断视网膜脱离!

日本Tsukazaki医院眼科系的Ohsugi H近日在Sci Rep杂志发表了一篇文章,题目为"Accuracy of deep learning, a machine-learning technology, using ultra-wide-field fundus ophthalmoscopy for detecting rhegmatogenous retinal detachment"

Am J Ophthalmol Case Rep:视网膜脱离和眼内压升高相关性的蛋白质组学分析!

爱荷华大学眼科实验室的Velez G近日在 Am J Ophthalmol Case Rep杂志发表了一篇文章,题目为"Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment" ,他们报道了一例眼压升高与视网膜脱离的病例。