mSphere:椰子油对念珠菌感染有效!

2015-11-19 Mechront 译 MedSci原创

马萨诸塞州塔夫斯大学的Carol Kumamoto教授进行了一项研究表明:椰子油对念珠菌属真菌感染有效!该成果发表在mSphere。她和她的同事提到:“免疫力低下或受损的如癌症患者、器官移植患者等,白色念珠菌常会从肠道进入血压,导致致命性感染,影响肾、肝、脾、肺、大脑和心瓣膜等,严重威胁生命安全。约有一半的系统性白色念珠菌感染患者会死亡!”Kumamoto教授补充到:“念珠菌是住院病人中血液感染最


马萨诸塞州塔夫斯大学的Carol Kumamoto教授进行了一项研究表明:椰子油对念珠菌属真菌感染有效!该成果发表在mSphere。

她和她的同事提到:“免疫力低下或受损的如癌症患者、器官移植患者等,白色念珠菌常会从肠道进入血液,导致致命性感染,影响肾、肝、脾、肺、大脑和心瓣膜等,严重威胁生命安全。约有一半的系统性白色念珠菌感染患者会死亡!”

Kumamoto教授补充到:“念珠菌是住院病人中血液感染最常见的微生物之一,感染该菌的患者常常病情严重,需要住院治疗。”

尽管对该感染,临床上诊疗常规或第一道防线是使用抗真菌药物,但这些药物的滥用会导致耐药菌株的出现,所以临床医生谨慎使用它们。

先前有体外研究表明,椰子油具有抗真菌特性;因为脂肪数量和类型的变化可以改变肠道微生物群。因此该团队设计了一个实验,探究不同的高脂肪饮食对小鼠肠道菌群的影响。

给老鼠喂养的高脂肪饮食含有椰子油、牛油或豆油,与此同时,还有普通饮食的老鼠。

所有老鼠在接种白色念珠菌前14天开始进食设计好的饮食,接种后,继续当前饮食。

研究结果表明,接种后21天,在椰子油喂养的老鼠胃中,白色念珠菌数量明显低于牛油、大豆油或标准饮食的老鼠。

Kumamoto教授提到:“椰子油与牛油或豆油喂养的老鼠相比,白色念珠菌定植数量少10倍!”

在进一步的实验中,Kumamoto和她的团队将牛油饮食变为椰子油,发现只有4天时间,胃内白色念珠菌定植数目就与一直椰子油喂养的老鼠差不多。

Kumamoto:“我们发现饮食是减少老鼠白色念珠菌的一个有效的方法。这一发现对人类很有意义。”

她解释说,他们想要找出椰子油产生这些影响的背后的机制,探究这些结果是否可以被复制。

如果一切按计划进行,该研究小组将启动一项临床试验,涉及系统性念珠菌感染的高危住院婴儿,探究椰子油对其是否有效。

原始出处:

Kearney T. W. Gunsalus,et al.Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans.mSphere.2015


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=156460, encodeId=a0c6156460a0, content=好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Thu Nov 17 21:01:59 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667758, encodeId=3630166e75844, content=<a href='/topic/show?id=90416291566' target=_blank style='color:#2F92EE;'>#椰子油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62915, encryptionId=90416291566, topicName=椰子油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 29 23:28:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670561, encodeId=a96116e056121, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 04 17:28:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51063, encodeId=c00a5106363, content=这也有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46671, encodeId=1a46466e1ba, content=不理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 23:17:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
    2016-11-17 小康子70

    好东东

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=156460, encodeId=a0c6156460a0, content=好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Thu Nov 17 21:01:59 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667758, encodeId=3630166e75844, content=<a href='/topic/show?id=90416291566' target=_blank style='color:#2F92EE;'>#椰子油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62915, encryptionId=90416291566, topicName=椰子油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 29 23:28:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670561, encodeId=a96116e056121, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 04 17:28:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51063, encodeId=c00a5106363, content=这也有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46671, encodeId=1a46466e1ba, content=不理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 23:17:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=156460, encodeId=a0c6156460a0, content=好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Thu Nov 17 21:01:59 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667758, encodeId=3630166e75844, content=<a href='/topic/show?id=90416291566' target=_blank style='color:#2F92EE;'>#椰子油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62915, encryptionId=90416291566, topicName=椰子油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 29 23:28:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670561, encodeId=a96116e056121, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 04 17:28:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51063, encodeId=c00a5106363, content=这也有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46671, encodeId=1a46466e1ba, content=不理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 23:17:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=156460, encodeId=a0c6156460a0, content=好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Thu Nov 17 21:01:59 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667758, encodeId=3630166e75844, content=<a href='/topic/show?id=90416291566' target=_blank style='color:#2F92EE;'>#椰子油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62915, encryptionId=90416291566, topicName=椰子油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 29 23:28:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670561, encodeId=a96116e056121, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 04 17:28:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51063, encodeId=c00a5106363, content=这也有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46671, encodeId=1a46466e1ba, content=不理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 23:17:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
    2016-01-02 xyfg98

    这也有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=156460, encodeId=a0c6156460a0, content=好东东, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Thu Nov 17 21:01:59 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667758, encodeId=3630166e75844, content=<a href='/topic/show?id=90416291566' target=_blank style='color:#2F92EE;'>#椰子油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62915, encryptionId=90416291566, topicName=椰子油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 29 23:28:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670561, encodeId=a96116e056121, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Thu Feb 04 17:28:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51063, encodeId=c00a5106363, content=这也有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Sat Jan 02 00:21:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46671, encodeId=1a46466e1ba, content=不理解, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 23:17:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
    2015-12-18 三三五五

    不理解

    0

相关资讯

JCI:美研究发现抵御毛霉菌病的抗体

毛霉菌病是由被称为毛霉目真菌的特定类型真菌入侵病人的细胞所导致的,这是一种致命的感染,而且会攻击免疫系统被削弱的病人。在毛霉目真菌细胞表面上的一种被称为CotH的新型蛋白质让这种入侵成为了可能。 洛杉矶生医所发现新型蛋白CotH是毛霉目真菌入侵人类细胞因子 来自美国洛杉矶生物医学研究所(LA BioMed)的一个科研团队今天以网络提前出版的形式在《临床研究杂志》(

Journal of Oral Microbiology:口腔感染可致阿尔兹海默病

两位口腔科研究人员通过对200多篇探索口腔感染与阿尔茨海默病(AD)之间关系的综述认真分析后,得出结论:老年人患阿尔茨海默病与口腔微生物有关。世界各地的医生和研究人员都想知道阿尔茨海默病的生物标志物,因为全球近4400万人都饱受阿尔茨海默病的困扰。奥斯陆大学教授 Ingar Olsen对口腔细菌进行了数十年的研究后,将重点放在口腔细菌与AD之间的关系。他联合中央兰开夏大学口腔研究小组的高级研究员的

PNAS:科学家发现新型真菌病毒

由Robert Coutts博士领导的研究人员发现了一种全新类型的真菌病毒。这项研究发表在《美国国家科学院院刊》(PNAS)上。 这种病毒感染烟曲霉菌型真菌,该细菌能引起人类患曲霉病。这种真菌靶向感染肺器官,并且是免疫力低下的个体发病率和死亡率的主要原因。 这种真菌病毒称为烟曲霉菌-1(AfuTmV-1),是由四条双链核糖核酸(dsRNA)和具有独特序列特征的基因染色体组组成。与几乎所有病

PLoS Pathog:揭示威胁艾滋病患者生命的致死性真菌

近日,来自美国杜克大学的研究人员通过研究指出了长期以来使得AIDS患者病情加重的真菌感染的环境来源,相关研究成果刊登于国际杂志PLoS Pathogens上。 这种感染性真菌名为格特隐球菌(Cryptococcus gattii),其是隐球菌属中的一种,易引发肺部和大脑感染,往往使得患者致死,其也是引发AIDS患者的其中一个主要原因。 文章中,研究者发现三种树种:卡内里松、桃金娘科常绿树和

IJMM:真菌agarikon或可作为新一代的抗病利器

近日,真菌学家Paul Stamets向人们展示了一种名为agarikon的真菌对健康的益处,agarikon生长在北美及欧洲的森林树木上,研究者在Huffington Post(赫芬顿邮报)上描述了这种真菌的抗细菌及真菌的能力,同时还强调要保护好原始的森林树木以便这种抗菌真菌可以一直生长下去。 Agarikon真菌生长于树枝上,类似于一个大的马蜂窝,历史记载美洲土著人曾将这种真菌磨碎,利

Immunity:抗真菌免疫反应机理是这样

真菌广泛存在与我们身处的环境中,它们对我们的身体健康也具有重要影响。我们的肺部经常暴露于空气中,因而会接触大量的曲霉与镰孢菌孢子,进而引发感染;我们的粘膜系统也经常会有共生真菌的存在,包括念珠菌与霉菌等。曲霉与镰孢菌感染是造成角膜溃疡眼盲症的主要原因。总体上来说,每年遭受真菌感染的人群占据全球人口的25%,其中一些严重的疾病(念珠菌病,肺囊虫病,隐球菌病)每年得病人数超过2百万,致死率超过50%。