JAMA Netw Open: 想要减肥效果好,那就在10点前入睡吧!

2021-07-02 MedSci原创 MedSci原创

睡的晚,会变胖,中午补觉也没用!

肥胖是一个不断演变的公共卫生问题,导致糖尿病血管疾病、癌症和过早死亡的严重健康后果。在全球范围内,自 1980 年以来,成年人肥胖的患病率翻了一番,这与现代社会睡眠持续时间的减少相似睡眠不足正变得越来越普遍,大约三分之一的成年人每晚睡眠不足 6 小时。现有的流行病学研究广泛表明,慢性睡眠不足行为与体重增加和肥胖的风险有关,然而,没有关于起床和入睡的最佳时间(即就寝时间)的指南。

来源:pixabay

2021630发表在JAMA Netw Open的一项研究表明睡的晚和夜间睡眠时间短与全身肥胖和腹部肥胖的风险增加有关,白天午睡时间延长并没有降低风险,而且还与腹部肥胖风险增加有关,尤其是在女性中。

 

这项大型、跨国、基于人群的横断面研究使用了来自 26 个国家的 60 个研究中心的参与者的数据,参与者年龄在35 至 70 岁之间研究员使用基线标准化问卷获得每位参与者通常的睡眠时间行为、平均夜间睡眠时间和每日小睡行为。睡眠时间行为包括就寝时间和起床时间, 还记录了每日习惯性午睡或午睡的持续时间。慢性短睡眠定义为平均夜间睡眠时间少于 6 小时,,慢性睡眠剥夺定义为平均夜间睡眠时间少于 5 小时。

就寝时间分为 5 个亚组:上午6晚上8晚上8晚上10 、晚上10至午夜、午夜至凌晨 2凌晨2早上6起床时间分为 3 个子组:凌晨4之前、凌晨4凌晨6下午6之后上午

主要结果是肥胖的患病率,进一步明确为一般肥胖和腹部肥胖。根据世界卫生组织 (WHO) 的定义,一般肥胖被定义为 BMI 为 30 或更高。根据成人治疗小组 III 标准,腹部肥胖被定义为男性腰围大于 102 厘米或女性腰围大于 88 厘米

来源:CDC

研究结果发现晚上8到 10之间的就寝时间相比,晚睡与全身肥胖(AOR,1.20;95% CI,1.12-1.29)和腹部肥胖(AOR,1.20;95% CI,1.12-1.28)相关,尤其是在凌晨2点到 6点之间睡觉的参与者(一般肥胖:AOR,1.35;;腹部肥胖:AOR,1.38)。

 睡眠时间与一般肥胖和腹部肥胖的关系的多层次Logistic回归分析

少于 6 小时的短夜睡眠与一般肥胖相关(例如,<5 小时:AOR,1.27),但较长的午睡时间与较高的腹部肥胖患病率相关(例如,≥1 小时: AOR,1.39)。白天睡觉(即晚上8点之前)和起床时间都与肥胖无关。

 夜间睡眠和午睡时间与一般肥胖和腹部肥胖的关系的多级Logistic回归分析

综上本横断面研究发现,晚睡时间和夜间睡眠时间短与肥胖患病风险增加有关,战略性体重控制计划还应鼓励早睡,避免夜间睡眠时间短,以减轻肥胖流行。

参考文献Tse LA, Wang C, Rangarajan S, et al. Timing and Length of Nocturnal Sleep and Daytime Napping and Associations With Obesity Types in High-, Middle-, and Low-Income Countries. JAMA Netw Open. 2021;4(6):e2113775. doi:10.1001/jamanetworkopen.2021.13775

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    2022-03-02 jing0309

    早睡减肥

    0

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    2021-07-10 canlab
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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2022-02-13 feather89
  5. 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    2021-07-06 1453df99m58暂无昵称

    肥胖是一个不断演变的公共卫生问题,导致糖尿病、心血管疾病、癌症和过早死亡的严重健康后果。

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-05 SR~young海东

    11点胆经当令排毒

    0

  7. 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topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 13 17:40:37 CST 2022, time=2022-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996953, encodeId=f679996953b6, content=肥胖是一个不断演变的公共卫生问题,导致糖尿病、心血管疾病、癌症和过早死亡的严重健康后果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Tue Jul 06 23:27:18 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996591, encodeId=5f61996591c9, content=11点胆经当令排毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-04 lshanp

    大样本,结果可信,有价值,所以发表的期刊更好

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1198859, encodeId=af7211988598d, content=早睡减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220313/1fccd8869aca4c2bbabb274c6aada833/8cdb5c5762b54b208703fcac43dcca47.jpg, createdBy=872f5678021, createdName=jing0309, createdTime=Wed Mar 02 21:12:50 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734392, encodeId=9ffb1e3439233, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, 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topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 13 17:40:37 CST 2022, time=2022-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996953, encodeId=f679996953b6, content=肥胖是一个不断演变的公共卫生问题,导致糖尿病、心血管疾病、癌症和过早死亡的严重健康后果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Tue Jul 06 23:27:18 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996591, encodeId=5f61996591c9, content=11点胆经当令排毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Jul 05 22:27:27 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996079, encodeId=21dc9960e9c8, content=大样本,结果可信,有价值,所以发表的期刊更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210704/cdd1076905df433c93873ae6d3d51aef/eae5c73864694494acb8435eb7d2e9bb.jpg, createdBy=ec7b92572, createdName=lshanp, createdTime=Sun Jul 04 12:46:41 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995937, encodeId=34ed99593e51, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-03 Avigo

    了解了解

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1198859, encodeId=af7211988598d, content=早睡减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220313/1fccd8869aca4c2bbabb274c6aada833/8cdb5c5762b54b208703fcac43dcca47.jpg, createdBy=872f5678021, createdName=jing0309, createdTime=Wed Mar 02 21:12:50 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734392, encodeId=9ffb1e3439233, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Sat Jul 10 05:40:37 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070985, encodeId=a72320e098505, content=<a href='/topic/show?id=7e50312e06a' target=_blank style='color:#2F92EE;'>#减肥效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31270, encryptionId=7e50312e06a, topicName=减肥效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Apr 22 22:40:37 CST 2022, time=2022-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729012, encodeId=14981e29012db, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 13 17:40:37 CST 2022, time=2022-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996953, encodeId=f679996953b6, content=肥胖是一个不断演变的公共卫生问题,导致糖尿病、心血管疾病、癌症和过早死亡的严重健康后果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Tue Jul 06 23:27:18 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996591, encodeId=5f61996591c9, content=11点胆经当令排毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Mon Jul 05 22:27:27 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996079, encodeId=21dc9960e9c8, content=大样本,结果可信,有价值,所以发表的期刊更好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210704/cdd1076905df433c93873ae6d3d51aef/eae5c73864694494acb8435eb7d2e9bb.jpg, createdBy=ec7b92572, createdName=lshanp, createdTime=Sun Jul 04 12:46:41 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995937, encodeId=34ed99593e51, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-02 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1198859, encodeId=af7211988598d, content=早睡减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220313/1fccd8869aca4c2bbabb274c6aada833/8cdb5c5762b54b208703fcac43dcca47.jpg, createdBy=872f5678021, createdName=jing0309, createdTime=Wed Mar 02 21:12:50 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734392, encodeId=9ffb1e3439233, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, 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topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 13 17:40:37 CST 2022, time=2022-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996953, encodeId=f679996953b6, content=肥胖是一个不断演变的公共卫生问题,导致糖尿病、心血管疾病、癌症和过早死亡的严重健康后果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bd984965877, createdName=1453df99m58暂无昵称, createdTime=Tue Jul 06 23:27:18 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996591, encodeId=5f61996591c9, content=11点胆经当令排毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210624/3da0b4e87d244fc8964a8bc9c1f7d3b8/e4798d77bda342298fe093b744b40344.jpg, createdBy=e2623291388, createdName=Avigo, createdTime=Sat Jul 03 23:56:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036716, encodeId=3d7a1036e16a8, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047383, encodeId=962b104e38337, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Jul 02 22:40:37 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-02 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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早上可以喝杯咖啡。方便的话,步行或骑自行车上班,晚上将电子产品调暗

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睡眠模式违背其自然生理时钟的人更有可能患抑郁症和健康水平处于较低。

你几点睡觉?84万人基因研究发现,睡眠中点提前一小时可将抑郁风险降低23%

一项针对84万人的遗传学研究发现,将睡眠时间提前一个小时,就能将抑郁症的风险降低23%。

拓展阅读

减重高达25.5%!JAMA子刊:3大策略,助力减肥更显著、更持久

《医学新视点》对主要的策略(包括生活方式干预、抗肥胖药物治疗、代谢和减肥手术)进行了介绍。

Nature子刊:熬夜加班,代谢崩溃!中南大学揭示了轮班导致肥胖和代谢紊乱的关键原因

该研究确定了轮班引起的昼夜节律紊乱和肥胖机制,进一步揭示了缓解轮班工人代谢紊乱的潜在治疗靶点,从而为轮班工人提供更好的健康指导。

Nature:当停用肥胖治疗药物后会发生什么?

停药后,许多患者体重迅速恢复,显示出身体努力恢复到其自然重量点的趋势,这一现象被肥胖专家Arya Sharma形容为“紧绷的橡皮筋”效应。

Genes & Diseases:Junli Liu/Yibing Wang教授团队总结肝因子在肥胖中的作用及其潜在的治疗意义

文章总结了肝因子在肥胖症中的作用及其在治疗干预中的潜在意义。

Nat Metab:难怪减肥这么难!肥胖让你的线粒体碎成渣,加速脂肪堆积

该研究证明,高脂肪饮食(HFD)喂养导致雄性小鼠腹股沟白色脂肪细胞线粒体断裂,导致氧化能力降低,这一过程依赖于小GTPase RalA。

CMI:复旦大学何睿/李华斌揭示肥胖个体对金黄色葡萄球菌更易感的潜在机理

该研究发现角化细胞中的趋化素-CMKLR1轴损害先天宿主对皮肤金黄色葡萄球菌感染的防御。