Experimental Physiology:孕期吸烟增加宝宝肥胖风险

2018-11-26 悠然 生物探索

物质水平的提高,随之而来的是儿童肥胖问题也在逐年走高。在英国有20%的儿童肥胖,科学家一直在为降低儿童肥胖风险而努力。近日,最新一项研究证明,除了饮食、运动和环境因素等,母亲孕期吸烟,也会增加宝宝肥胖风险。

众所周知,母亲在怀孕期间吸烟会导致所生的婴儿早产和低出生体重的风险增加。然而,最近的研究表明,母亲在怀孕期间吸烟还会导致婴儿肥胖。研究结果以 “Smoking during pregnancy increases chemerin expression in neonatal tissue”为题发表在《Experimental Physiology》杂志上。

论文主要作者Leryn Reynolds和其同事试图揭示这一现象的背后机制。

据了解,Chemerin是一种由脂肪细胞产生的蛋白质,在肥胖者的血液中存在较高水平。进一步研究发现,母亲怀孕期间吸烟的婴儿皮肤皮肤中,Chemerin更为普遍。更详细的分析表明,这种增加的表达与降低的DNA甲基化相对应,这是调节Chemerin表达的一种机制。这种蛋白与肥胖有关,因此表达增加会增加婴儿肥胖的可能性。

这些结果提示,怀孕期间吸烟可能导致对脂肪细胞发育和肥胖起重要作用的基因调控的改变。

但这项研究有一个局限性,由于研究只在男性新生儿中进行,因此研究结果不一定适用于女性新生儿。接下来,研究人员计划检测男婴和女婴的脐带中分离的细胞中的Chemerin水平。

论文作者Kevin Pearson博士表示,我们想了解清楚为什么吸烟者所生的婴儿会患晚期疾病的风险,并希望研究改进戒烟计划或者提高吸烟者运动水平的方法,以改善其对后代带来的负面结果。

原始出处:

Leryn J. Reynolds  Niraj R. Chavan  Logan B. DeHoff, et al. Smoking during pregnancy increases chemerin expression in neonatal tissue. Experimental Physiology, 2018.

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    2019-01-13 qjddjq
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    2019-07-21 lixiaol
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    2019-06-06 feather89
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1785923, encodeId=5e4b1e8592324, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Sun Jan 13 11:21:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951996, encodeId=502a1951996ea, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Sun Jul 21 15:21:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788892, encodeId=c1f41e88892fa, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Mar 08 18:21:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785929, encodeId=d7b11e85929ea, content=<a href='/topic/show?id=bd0de16748' target=_blank style='color:#2F92EE;'>#experimental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7167, encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Wed Jun 12 10:21:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727755, encodeId=80e81e27755c1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Jun 06 20:21:00 CST 2019, time=2019-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249840, encodeId=08a81249840e4, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Mon Nov 26 13:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353698, encodeId=c006353698c2, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Nov 26 11:29:33 CST 2018, time=2018-11-26, status=1, ipAttribution=)]
    2018-11-26 orangesking

    0

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