JASN:心血管疾病住院与随后的ESKD风险

2020-01-11 xing.T MedSci原创

由此可见,主要的心血管疾病事件与ESKD相关,与肾脏危险因素无关。特别是心衰与ESKD密切相关。研究人员的发现强调了在心血管疾病患者中监测和管理肾脏疾病的重要性。射血分数保留相对降低的心力衰竭对ESKD的潜在影响值得进一步研究。

心肾综合征是一个众所周知的概念,但是,关于心血管疾病是否会增加ESKD长期风险的数据很少。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,研究人员评估了参加社区动脉粥样硬化风险研究的个体主要心血管疾病(心力衰竭、心房颤动、冠心病和卒中)住院与随后ESKD风险之间的关联。

该分析包含了9047位在第四次研究访问时未患上心血管疾病的个体。将每个相关的心血管疾病事件事件作为随时间变化的暴露量输入多变量Cox比例风险模型中,以估计风险比。

在平均17.5年的随访中,有2598例因心血管疾病住院的病例(心力衰竭,n=1269;心房颤动,n=1337;冠心病,n=696;卒中,n=559)。210例ESKD事件。主要心血管疾病的发生与ESKD风险增加相关,心衰风险最高(风险比为11.40; 95%的置信区间为8.38至15.50),其次是冠心病、房颤和卒中。当研究人员分别分析射血分数保留的心力衰竭和射血分数降低的心力衰竭时,射血分数保留的心力衰竭风险在名义上较高。

由此可见,主要的心血管疾病事件与ESKD相关,与肾脏危险因素无关。特别是心衰与ESKD密切相关。研究人员的发现强调了在心血管疾病患者中监测和管理肾脏疾病的重要性。射血分数保留相对降低的心力衰竭对ESKD的潜在影响值得进一步研究。

原始出处

Junichi Ishigami,et al.Incident Hospitalization with Major Cardiovascular Diseases and Subsequent Risk of ESKD: Implications for Cardiorenal Syndrome.JASN,2020.https://jasn.asnjournals.org/content/early/2020/01/08/ASN.2019060574

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    2020-02-01 chenhongpeng
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    2020-01-18 sallylee_87

    厉害了

    0

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