Alzheimer&Dementia:正名!创伤性脑损伤和PTSD与阿尔茨海默病病理无关

2022-07-02 网络 网络

TBI和/或PTSD与AD生物标志物的升高没有关系。暴露的退伍军人较差的认知状态可能是由于其他合并的病症。

创伤性脑损伤(TBI)与包括认知障碍和神经系统疾病长期后果有关。中度至重度创伤性脑损伤史与所有原因的痴呆风险大约翻倍有关。创伤后应激障碍(PTSD)是一种精神疾病,可能是在暴露于包括军事战斗在内的创伤性压力之后出现的。与TBI一样,PTSD与晚年痴呆症的发展有关。

目前的流行病学研究报告了TBI和PTSD与临床诊断的阿尔茨海默病(AD)之间的关联。为此,来自加州大学的学者开展了相关研究,旨在发现TBI/PTSD与生物标志物定义的AD之间的关联。

该研究确定了289名患有TBI和/或PTSD的非痴呆退伍军人和对照组,他们接受了临床评估、脑脊液(CSF)收集、磁共振成像(MRI)、淀粉样β(Aβ)和tau正电子发射断层扫描,以及脂蛋白E测试。对参与者进行了长达5.2年的随访。

结果显示,与对照组相比,暴露组(TBI、PTSD和TBI+PTSD)具有更高的轻度认知障碍(MCI:P < .0001)和更差的MMSE检查分数(PTSD:P = .008;TBI & PTSD:P = .009)。在其他认知评分、Aβ或tau累积或大多数纵向测量方面没有明显的差异。

研究人员为一部分退伍军人获得了平均1.8年(SD=1.2年;范围=0.9-5.2年)的纵向MRI,每人平均有2.3张图像。在受过12年教育且没有APOE ε4等位基因的65岁CU退伍军人中,海马体积(颅内总体积的百分比)仅在TBI组中明显下降了0.01(标准误差[SE]=0.004;P=0.01)。各组年变化率的差异没有达到显著性(P = .07)。

综上,TBI和/或PTSD与AD生物标志物的升高没有关系。暴露的退伍军人较差的认知状态可能是由于其他合并的病症。

 

参考文献:

Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers

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    2023-03-07 amyloid
  4. [GetPortalCommentsPageByObjectIdResponse(id=1818224, encodeId=c9571818224ca, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Jan 02 21:11:09 CST 2023, time=2023-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817201, encodeId=fe32181e20107, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Dec 31 09:11:09 CST 2022, time=2022-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025543, encodeId=84702025543c0, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Tue Mar 07 10:11:09 CST 2023, time=2023-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718166, encodeId=c2841e18166a4, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 11 16:11:09 CST 2022, time=2022-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335402, encodeId=1176133540221, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Jul 04 02:11:09 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398364, encodeId=17c813983643e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Mon Jul 04 02:11:09 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470571, encodeId=61c014e0571d0, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Mon Jul 04 02:11:09 CST 2022, time=2022-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230179, encodeId=a8d312301e951, content=哇塞,非常值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04825602095, createdName=ms1000001374430865, createdTime=Sat Jul 02 21:07:39 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
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    2022-07-02 ms1000001374430865

    哇塞,非常值得学习

    0

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 Alzheimer's&Dement:解读阿尔茨海默病和相关痴呆基因检测结果和准确进行风险评估要重视PTSD和TBI病史

PTSD和TBI病史将是解读ADRD基因检测结果和准确进行ADRD风险评估的重要组成部分。

Mol Psychiatry:PTSD不缓解可能与右侧海马CA1亚区初始体积较低有关

特定海马亚区的体积异常是与急性创伤后应激障碍未恢复相关的早期脆弱性特征

TP:IL-6、IL-10可以预测女性创伤后应激障碍患者的治疗结果

治疗前急性应激下的促炎性和抗炎性IL-6和IL-10水平可预测女性PTSD患者在一般症状负担和抑郁症状方面的治疗结果。