JCEM:美国成人低性激素结合球蛋白的定义、患病率及危险因素

2021-06-16 MedSci原创 MedSci原创

该研究明确了美国成年人低SHBG的标准。据估计,美国全国男性低SHBG的患病率为3.3%,女性为2.7%。

低性激素结合球蛋白(SHBG)与许多疾病相关,包括血管疾病、癌症、多囊卵巢综合征、关节炎和肝脏疾病。然而,低SHBG的定义及其在美国成年人中的患病率尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在定义低SHBG并确定其在美国成年人中的患病率和危险因素。

该队列研究纳入了来自美国国民健康和营养评估调查(NHANES)2013年至2016年期间20岁以上的成年人,他们空腹血清SHBG数据可用。该研究的主要结局指标为SHBG的定义、患病率和危险因素。

男性和女性SHBG的水平

该研究纳入了4093名成人,其平均 (SD) 年龄为47.5(17.0)岁。在1477名成人的“健康”参考亚组中,低SHBG定义为50岁以下男性SHBG<12.3 nmol/L,或50岁以上男性SHBG<23.5 nmol/L,或30岁以下女性SHBG<14.5 nmol/L,或30岁以上女性SHBG<21.9 nmol/L。据估计,美国全国男性低SHBG患病率为3.3%,女性为2.7%,总体为3.0%。男性和女性的这种疾病的危险因素包括较高的体重指数、糖尿病、种族、慢性阻塞性肺病、冠心病和吸烟。

由此可见,该研究明确了美国成年人低SHBG的标准。据估计,美国全国男性低SHBG的患病率为3.3%,女性为2.7%。

原始出处:

Yutang Wang.et al.Definition, prevalence, and risk factors of low sex hormone-binding globulin in US adults.JCEM.2021.https://doi.org/10.1210/clinem/dgab416

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    2022-01-12 achengzhao
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    2021-10-31 xzw113
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    2021-08-05 smallant2015
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    2021-06-17 ms8000000559199342

    学习了!

    0

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