Brain Stimul:三叉神经外部刺激是可安全有效的治疗局灶性耐药癫痫

2021-05-14 MedSci原创 MedSci原创

三叉神经外部刺激(ETNS)是一种紧急的、非侵入性的神经刺激疗法。既往研究显示,ETNS可降低局灶性耐药癫痫(DRE)的发作频率。近日,研究人员进行了一项随机试验,旨在确定ETNS对局灶性DRE患者的

三叉神经外部刺激(ETNS)是一种紧急的、非侵入性的神经刺激疗法。既往研究显示,ETNS可降低局灶性耐药癫痫(DRE)的发作频率。近日,研究人员进行了一项随机试验,旨在确定ETNS对局灶性DRE患者的长期疗效和耐受性,并探讨其疗效是否取决于致痫区(额叶或颞叶),以及其对情绪、认知功能、生活质量和三叉神经兴奋性的影响,研究结果已发表于Brain Stimul。

研究纳入40名额叶或颞叶DRE患者,不适合手术,随机分配到ETNS或常规医疗治疗。在3个月、6个月和12个月时评估疗效、副作用、情绪量表、神经心理测试和三叉神经兴奋性。

 

结果显示,受试者每月发作次数的中位数为15次,曾使用过12.5种抗癫痫药物。12个月后,ETNS组的反应者比例为50%,对照组为0%。ETNS组的癫痫发作频率比基线下降了-43.5%。颞部癫痫亚组的反应比额部癫痫亚组好(分别为55.56%和45.45%)。中位刺激强度为6.2毫安。ETNS治疗改善了患者的生活质量,但没有改善焦虑或抑郁症。长期的ETNS既不影响神经心理功能,也不影响三叉神经的兴奋性。没有观察到相关的不良事件。

综上所述,该研究结果表明,ETNS是一种有效且耐受性良好的局灶性DRE治疗方法。颞部癫痫患者的反应比额部癫痫患者好。该研究提供了二级证据,证明ETNS可减少局灶性DRE患者的发作频率。

 

原始出处:

 

Francisco Gil-López, et al., External trigeminal nerve stimulation for drug resistant epilepsy: A randomized controlled trial. Brain Stimul. Sep-Oct 2020;13(5):1245-1253. doi: 10.1016/j.brs.2020.06.005.  

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1739273, encodeId=43cf1e3927361, content=<a href='/topic/show?id=6a9f1959e07' target=_blank style='color:#2F92EE;'>#三叉神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19597, encryptionId=6a9f1959e07, topicName=三叉神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19e234497376, createdName=小华子, createdTime=Wed Mar 02 15:52:22 CST 2022, time=2022-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009703, encodeId=3ad62009e03af, content=<a href='/topic/show?id=c7804e581bc' target=_blank style='color:#2F92EE;'>#局灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47581, encryptionId=c7804e581bc, topicName=局灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Tue Jun 22 00:52:22 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965747, encodeId=e563965e4707, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6aac3004944, createdName=76996753, createdTime=Sat May 15 07:09:58 CST 2021, time=2021-05-15, status=1, ipAttribution=)]
    2021-05-15 76996753

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