SCI REP:主观认知功能下降患者血浆中tau蛋白水平如何变化!

2017-08-25 xing.T MedSci原创

总之,在SCD患者血浆中tau蛋白并不增加。此外,在验证队列中,血浆和脑脊液中tau蛋白之间缺乏相关性,这表明tau蛋白水平在两种体液中受到了不同因素的影响。

以前的研究已经证实阿尔茨海默病(AD)和AD引起的轻度认知功能障碍(MCI)患者血浆中tau蛋白水平增加。但目前还不清楚在主观认知功能减退(SCD)的MCI前期是否可以检测出血浆中增加的tau蛋白水平。

近日,Scientific reports 杂志上发表了一篇研究文章。在该研究中,研究人员检测了111名SCD患者和134名参与DZNE(德国神经退行性疾病研究中心)关于认知和痴呆的纵向研究(DELCODE)的年龄和性别匹配的认知功能正常的健康对照者血浆中tau蛋白水平。研究人员利用超灵敏的单分子阵列(Simoa)技术测量了血浆中tau蛋白浓度。

研究人员发现在控制了年龄、性别和受教育程度后,SCD(3.4 pg/ml)患者与健康对照者(3.6 pg/ml)相比,血浆中tau蛋白水平并无显著的差异(P=0.137)。此外,在45例SCD患者的亚组中,血浆中tau蛋白水平与脑脊液中Aβ42(r=0.073;P=0.634)、tau蛋白(r=-0.179;P=0.240)和p-tau181(r=-0.208;P=0.171)水平并无相关性。

总之,在SCD患者血浆中tau蛋白并不增加。此外,在验证队列中,血浆和脑脊液中tau蛋白之间缺乏相关性,这表明tau蛋白水平在两种体液中受到了不同因素的影响。

原始出处:

Stephan Müller,et al. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-08779-0

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    2019-07-10 1244ac4em41(暂无昵称)

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createdBy=55c610090940, createdName=szhvet, createdTime=Sun Aug 27 11:56:00 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237480, encodeId=a22623e480dc, content=不错的文章值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Aug 26 23:28:22 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237358, encodeId=732923e3581b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Sat Aug 26 12:29:52 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237344, encodeId=250f23e344dc, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Aug 26 10:46:47 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237229, encodeId=380623e2291e, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sat Aug 26 07:04:05 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237226, encodeId=411123e2263e, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Aug 26 06:57:18 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237190, encodeId=ab9423e190ab, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-27 szhvet
  5. [GetPortalCommentsPageByObjectIdResponse(id=369418, encodeId=ddc9369418fb, content=没有相关性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa4d2476243, createdName=1244ac4em41(暂无昵称), createdTime=Wed Jul 10 17:41:39 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034320, encodeId=a2fb203432025, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Jan 15 18:56:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 131****2916

    不错的文章值得学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=369418, encodeId=ddc9369418fb, content=没有相关性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa4d2476243, createdName=1244ac4em41(暂无昵称), createdTime=Wed Jul 10 17:41:39 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034320, encodeId=a2fb203432025, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Jan 15 18:56:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), 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createdBy=55c610090940, createdName=szhvet, createdTime=Sun Aug 27 11:56:00 CST 2017, time=2017-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237480, encodeId=a22623e480dc, content=不错的文章值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Aug 26 23:28:22 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237358, encodeId=732923e3581b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 海棠胜雪

    学习了

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 衣带渐宽

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=369418, encodeId=ddc9369418fb, content=没有相关性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa4d2476243, createdName=1244ac4em41(暂无昵称), createdTime=Wed Jul 10 17:41:39 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034320, encodeId=a2fb203432025, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Jan 15 18:56:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), 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createdBy=0d021989245, createdName=189****1577, createdTime=Sat Aug 26 07:04:05 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237226, encodeId=411123e2263e, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Aug 26 06:57:18 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237190, encodeId=ab9423e190ab, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 189****1577

    值得推荐一下

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=369418, encodeId=ddc9369418fb, content=没有相关性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa4d2476243, createdName=1244ac4em41(暂无昵称), createdTime=Wed Jul 10 17:41:39 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034320, encodeId=a2fb203432025, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Jan 15 18:56:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 明月清辉

    谢谢分享.学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=369418, encodeId=ddc9369418fb, content=没有相关性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa4d2476243, createdName=1244ac4em41(暂无昵称), createdTime=Wed Jul 10 17:41:39 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2034320, encodeId=a2fb203432025, content=<a href='/topic/show?id=2fda91215d2' target=_blank style='color:#2F92EE;'>#认知功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91215, encryptionId=2fda91215d2, topicName=认知功能下降)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Jan 15 18:56:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Aug 26 06:23:40 CST 2017, time=2017-08-26, status=1, ipAttribution=)]
    2017-08-26 龙胆草

    学习谢谢分享

    0

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