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Aging Cell：α-酮戊二酸可延缓年龄增长带来的生育力下降

2021-01-21 haibei MedSci原创

生殖衰老
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在最近的一项研究中，来自中国农业大学的研究人员考察了α-酮戊二酸（α-KG）与小鼠、猪和人类等哺乳动物生殖衰老的潜在关联。人类卵泡液中的α-KG水平随衰老有明显的降低趋势。

由于现代人生育年龄的推迟，延长有效生育年龄成为女性的普遍要求。卵巢在哺乳动物的生殖中起着核心作用。卵巢的保留和卵母细胞的能力随着年龄的增长而下降，这也被称为卵巢衰老(同义词：生殖衰老)，通常与生育力下降有关。

卵巢衰老比一般衰老发生得早得多。卵巢衰老最明显的特征是卵母细胞的质量和数量显著下降。例如，一个人类女性出生时大约有40万个带有初级卵母细胞的原始卵泡。这些初级卵母细胞一直停滞在减数第一次分裂的前阶段，直到性成熟。经期开始后，平均每月会丢失1000个初级卵母细胞，到了中年(37岁左右)，一个女性的卵子只剩下25000个左右。因此，保存卵泡库，保持卵母细胞质量，将延缓卵巢衰老，延长女性生育期。

在最近的一项研究中，来自中国农业大学的研究人员考察了α-酮戊二酸（α-KG）与小鼠、猪和人类等哺乳动物生殖衰老的潜在关联。人类卵泡液中的α-KG水平随衰老有明显的降低趋势。

为了探讨其机制，研究人员选择小鼠作为动物模型。α-KG可以抑制ATP合成酶，能量代谢的改变引发营养传感器下调mTOR通路。这些事件不仅有利于一般的衰老过程，还能维持卵巢功能，延缓生殖功能衰退。

考虑到α-KG作为能量代谢中天然存在的分子的安全性，其在包括人类在内的大型哺乳动物生殖中的效用值得进一步研究。

 

原始出处：

Zhenzhen Zhang et al. α‐ketoglutarate delays age‐related fertility decline in mammals. Aging Cell (2021). 

 

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    2021-01-30 zhaozhouchifen

    #Cell#

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    2022-01-06 维他命

    #CEL#

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    #生育力#

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    2021-01-21 zb1235672

    #α-酮戊二酸#

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    2021-01-21 lifefamily

    #α-酮戊二酸#这是一明确的抗#衰老#潜在的药物，至少比NMN靠谱

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