JCEM:绝经年龄与绝经后骨密度和骨折风险相关

2021-09-20 MedSci原创 MedSci原创

与实际年龄相比,FMP后年份与绝经后BMD之间的相关性更强,更年期提前与骨折风险增加相关。

45岁之前绝经是骨折的危险因素,但90%的女性绝经发生在45岁或更晚。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确45岁或之后绝经的女性,是否:1)自末次月经(FMP)起的年数与绝经后骨密度(BMD)之间的相关性比实际年龄更密切;2)FMP的年龄越小,骨折越多。

该研究为全国妇女健康研究,包含一个多样化的非卧床妇女队列(基线时处于绝经前或围绝经期早期,有15次年度的随访评估)。该研究的主要观察指标为1)绝经后腰椎(LS)或股骨颈(FN)BMD(N=1038);2)骨折时间(N=1554)。

研究人员使用多变量线性回归调整年龄、BMI、吸烟、酒精摄入量、基线LS或FNBMD、基线MT分期和研究地点,FMP后每增加一年分别与绝经后LS和FNBMD降低0.006(p<0.0001)和0.004(p<0.0001)g/cm2相关。自FMP以来,年龄与FNBMD无关。在Cox比例风险回归中,考虑到种族/民族、BMI、吸烟、饮酒、既往骨折、糖尿病状况、接受骨修复药物/补充剂和研究地点等因素,FMP的年龄每减少一岁发生骨折的风险升高5%(p=0.02)。

由此可见,与实际年龄相比,FMP后年份与绝经后BMD之间的相关性更强,更年期提前与骨折风险增加相关。

原始出处:

Albert Shieh.et al.Associations of age at menopause with postmenopausal bone mineral density and fracture risk in women.JCEM.2021.https://doi.org/10.1210/clinem/dgab690

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    2022-06-30 achengzhao
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    2022-03-09 仁心济世
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    2021-09-22 zxxiang
  7. [GetPortalCommentsPageByObjectIdResponse(id=2055029, encodeId=cb72205502951, content=<a href='/topic/show?id=dd47e8901d9' target=_blank style='color:#2F92EE;'>#绝经年龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78901, encryptionId=dd47e8901d9, topicName=绝经年龄)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Wed May 11 08:51:07 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063511, encodeId=278920635114f, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Jun 30 03:51:07 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778129, encodeId=43d81e7812974, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Mar 09 12:51:07 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257289, encodeId=b2a1125e289e7, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390439, encodeId=7103139043977, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631658, encodeId=52df16316583c, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053321, encodeId=6e021053321c7, content=我想说,不啊嘛, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Mon Sep 20 19:52:16 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053305, encodeId=b5a91053305b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200822/b4ea7b614a2f44058d2ee7550da5aa99/0a410f15b95946019df4b84086b90665.jpg, createdBy=64642447770, createdName=123eaf1bm35暂无, createdTime=Mon Sep 20 18:20:00 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 公子墨

    我想说,不啊嘛

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2055029, encodeId=cb72205502951, content=<a href='/topic/show?id=dd47e8901d9' target=_blank style='color:#2F92EE;'>#绝经年龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78901, encryptionId=dd47e8901d9, topicName=绝经年龄)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Wed May 11 08:51:07 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063511, encodeId=278920635114f, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Jun 30 03:51:07 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778129, encodeId=43d81e7812974, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Mar 09 12:51:07 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257289, encodeId=b2a1125e289e7, content=<a href='/topic/show?id=cdfce8879b1' target=_blank style='color:#2F92EE;'>#绝经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78879, encryptionId=cdfce8879b1, topicName=绝经)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390439, encodeId=7103139043977, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631658, encodeId=52df16316583c, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Wed Sep 22 05:51:07 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053321, encodeId=6e021053321c7, content=我想说,不啊嘛, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211009/0ae31fdf59e2426db40ceac2aaa8f957/acd095b2a61d462f92190dc941c830f8.jpg, createdBy=51fa5536016, createdName=公子墨, createdTime=Mon Sep 20 19:52:16 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053305, encodeId=b5a91053305b1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200822/b4ea7b614a2f44058d2ee7550da5aa99/0a410f15b95946019df4b84086b90665.jpg, createdBy=64642447770, createdName=123eaf1bm35暂无, createdTime=Mon Sep 20 18:20:00 CST 2021, time=2021-09-20, status=1, ipAttribution=)]
    2021-09-20 123eaf1bm35暂无

    学习了

    0

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