JAMA:急性心梗合并的亚临床甲减或无需治疗!随机临床试验

2020-07-24 朱朱 中国循环杂志

甲状腺激素在调节心肌收缩的过程中发挥关键的作用。既往研究表明,急性心梗患者如果合并亚临床甲减(促甲状腺激素水平升高、而甲状腺素水平正常),预后较差。

甲状腺激素在调节心肌收缩的过程中发挥关键的作用。既往研究表明,急性心梗患者如果合并亚临床甲减(促甲状腺激素水平升高、而甲状腺素水平正常),预后较差。


我国海南学者发现,合并亚临床甲减的冠心病患者放支架后效果较差。


那么,对于合并亚临床甲减的急性心梗患者来说,补充甲状腺素是否有益呢?


7月21日,发表在JAMA杂志上的一项随机临床试验表明,在这类患者中,与应用安慰剂相比,补充左旋甲状腺素1年后,并没有明显改善左室射血分数。


研究者认为,该研究结果并不支持治疗急性心梗患者合并的亚临床甲减,在急性心梗患者中筛查亚临床甲减也没有正当理由。目前仍不清楚亚临床甲减是否为心脏病患者预后变差的原因。


值得一提的是,该研究中患者的平均促甲状腺素水平为5.7 mU/L,大约40%的患者基线左室射血分数正常。


因此,研究者指出,对于更加严重的亚临床甲减(甲状腺素水平>10 mIU /L)或基线左室功能减退的患者,目前不清楚补充激素治疗是否有益。


而且,在该研究中,在根据入院时甲状腺功能诊断的亚临床甲减患者中,相当一部分患者7~10天后复查是,甲状腺功能已恢复正常了。这说明,仅凭一次甲状腺功能检查结果来诊断亚临床甲减并不可靠,这类患者需要在数周后复查甲状腺功能。


关于亚临床甲减,目前大多数指南建议,促甲状腺激素水平>10 mIU /L时(正常范围为0.4~4.0 mIU/L)应补充甲状腺素。


但2018年JAMA杂志上发表的一项覆盖21项随机对照试验的Meta分析显示,亚临床甲减患者常规接受甲状腺激素治疗约3~18个月后,虽然与安慰剂相比,促甲状腺激素下降,但对生活质量、甲减相关症状、抑郁症状、疲劳、认知功能改善、肌肉力量、血压以及体重指数等均无改善。


2019年发表在BMJ上的一项临床实践指南明确提出,几乎全部亚临床甲减患者均不建议常规给予激素治疗,仅监测甲状腺功能即可,因为激素治疗不会改善这类患者的生活质量或症状,包括情绪低落和疲劳。


这项最新的随机、双盲、安慰剂对照临床试验一共纳入来自英国6家医院的95例合并亚临床甲减的急性心梗患者,随机给予左旋甲状腺素(46例)或安慰剂(49例)治疗。


左旋甲状腺素以25 μg开始滴定,直到血清甲状腺素水平降至0.4~2.5 mIU/L;安慰剂以等剂量进行治疗;均以胶囊形式给药,每日一次,共治疗52周。


接受左旋甲状腺素治疗的患者基线平均左室射血分数为51.3%,治疗52周时,其左室射血分数为53.8%,并没有显着改善;安慰剂组患者的平均左室射血分数从54%变为56.1%。两组患者左室射血分数的变化无明显差别。


另外,两组患者的平均左室体积、心肌梗死面积、不良事件、患者自我报告的健康状态、健康相关的生活质量、抑郁等均无明显差别。


左旋甲状腺素组和安慰剂组中血管不良事件发生率分别为33.3%和36.7%。这说明,左旋甲状腺素治疗并没有增加不良反应风险。


治疗52周时,左旋甲状腺素组的促甲状腺素水平明显低于安慰剂组,而游离T4水平明显高于安慰剂组。


该研究纳入的患者平均年龄为63.5岁,76.6%为男士,69.1%为急性ST段抬高型心肌梗死患者。治疗结束时,甲状腺素组的日均剂量为50 μg。

原始出处:
Avais Jabbar 1 2, Lorna Ingoe 2 3, Shahid Junejo 4, et al.Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.JAMA. 2020 Jul 21;324(3):249-258. doi: 10.1001/jama.2020.9389.

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    2020-07-24 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661394, encodeId=5fa316613943b, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Tue Jul 06 02:24:43 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308398, encodeId=dd3b13083989a, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Sun Jul 26 01:24:43 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341330, encodeId=d23a13413307c, content=<a href='/topic/show?id=0cb769e593b' target=_blank style='color:#2F92EE;'>#甲减#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69759, encryptionId=0cb769e593b, topicName=甲减)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jul 26 01:24:43 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036179, encodeId=fe0e10361e924, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038946, encodeId=b85d1038946d3, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050248, encodeId=8eba10502483d, content=大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2020-07-24 肿瘤克星

    高质量研究,读起来真爽,谢谢梅斯

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1661394, encodeId=5fa316613943b, content=<a href='/topic/show?id=5f119844112' target=_blank style='color:#2F92EE;'>#随机临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98441, encryptionId=5f119844112, topicName=随机临床试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbb125274547, createdName=ms117281293605716, createdTime=Tue Jul 06 02:24:43 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308398, encodeId=dd3b13083989a, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Sun Jul 26 01:24:43 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341330, encodeId=d23a13413307c, content=<a href='/topic/show?id=0cb769e593b' target=_blank style='color:#2F92EE;'>#甲减#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69759, encryptionId=0cb769e593b, topicName=甲减)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jul 26 01:24:43 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036179, encodeId=fe0e10361e924, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038946, encodeId=b85d1038946d3, content=高质量研究,读起来真爽,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050248, encodeId=8eba10502483d, content=大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Fri Jul 24 13:24:43 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2020-07-24 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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